口腔鳞状细胞癌 (OSCC) 约占所有口腔癌的 90%，是全球第八大常见癌症。尽管在治疗 OSCC 方面取得了进展，但总体预后仍然较差，生存率约为 50-60%，这主要是由于肿瘤大小和复发。晚期诊断的挑战和当前方法的局限性强调迫切需要微创技术来实现早期检测和治疗，这对于改善这种侵袭性口腔癌的预后至关重要。目前的研究旨在揭示肿瘤特异性代谢物谱，以确定候选生物标志物，并发现涉及癌症发生和进展的潜在途径，这些途径可用作诊断和治疗目的的新靶点。代谢组学是一种先进的技术方法，用于识别不同样本类型（生物体液和组织）中的代谢物。由于 OSCC 促进代谢重编程受遗传易感性和环境因素（包括烟草和酒精消费以及病毒感染）综合影响，因此通过筛查鉴定不同的代谢物可能有助于诊断这种疾病。此外，研究表明在表观遗传修饰的催化过程中代谢物的使用，表明表观遗传学和代谢之间的联系。在这篇综述中，我们将重点关注环境、遗传和表观遗传对 OSCC 代谢组改变的影响之间的联系。此外，我们将讨论肿瘤代谢的治疗靶点，这可能会预防口腔肿瘤的生长、转移和耐药性。© 2024。作者。

Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is the eighth most common cancer worldwide. Despite progress in managing OSCC, the overall prognosis remains poor, with a survival rate of around 50-60%, largely due to tumor size and recurrence. The challenges of late-stage diagnosis and limitations in current methods emphasize the urgent need for less invasive techniques to enable early detection and treatment, crucial for improving outcomes in this aggressive form of oral cancer. Research is currently aimed at unraveling tumor-specific metabolite profiles to identify candidate biomarkers as well as discover underlying pathways involved in the onset and progression of cancer that could be used as new targets for diagnostic and therapeutic purposes. Metabolomics is an advanced technological approach to identify metabolites in different sample types (biological fluids and tissues). Since OSCC promotes metabolic reprogramming influenced by a combination of genetic predisposition and environmental factors, including tobacco and alcohol consumption, and viral infections, the identification of distinct metabolites through screening may aid in the diagnosis of this condition. Moreover, studies have shown the use of metabolites during the catalysis of epigenetic modification, indicating a link between epigenetics and metabolism. In this review, we will focus on the link between environmental, genetic, and epigenetic influences in metabolomic alterations in OSCC. In addition, we will discuss therapeutic targets of tumor metabolism, which may prevent oral tumor growth, metastasis, and drug resistance.© 2024. The Author(s).