研究动态
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程序性流产、提供者发起的早产和癌症孕妇的生存:一项基于人群的队列研究。

Procedural abortion, provider-initiated preterm delivery and survival in pregnant people with cancer: A population-based cohort study.

发表日期:2024 Aug 21
作者: Amy Metcalfe, Zoe F Cairncross, Joel G Ray, Lorraine Shack, Gregg Nelson, Christine M Friedenreich, Khokan Sikdar, Sarka Lisonkova, Carly A McMorris, Parveen Bhatti, Deshayne B Fell
来源: Bjog-Int J Obstet Gy

摘要:

评估程序性流产或服务提供者发起的早产是否与癌症孕妇生存率的提高相关。基于人群的回顾性队列研究。加拿大阿尔伯塔省和安大略省,2003-2016 年。诊断年龄为 18-50 岁的女性妊娠<20周”(用于评估程序性流产)或<37周”(用于评估提供者发起的分娩)患有癌症。Cox比例风险模型评估了与程序性流产相关的全因死亡率以及提供者发起的早产,根据癌症部位、诊断阶段和年龄进行调整。荟萃分析汇总了两个省的结果。全因死亡率。有 512 名孕妇在妊娠 <20 周时被诊断出患有癌症,782 名孕妇在妊娠 <37 周时被诊断出患有癌症。程序性流产(调整后的风险比[aHR] = 1.39,95% CI:0.32-6.17)和提供者发起的早产(aHR = 1.17,95% CI:0.76-1.81)与调整后的生存率改善无关。年龄、诊断阶段和癌症部位。程序性流产和医疗服务提供者发起的早产都与诊断患有癌症的孕妇的生存率提高无关。然而,这些产科干预措施是高度个人化的决定,最好由孕妇与其护理人员协商后决定。© 2024 作者。 BJOG:约翰·威利出版的国际妇产科杂志
To assess whether procedural-induced abortion or provider-initiated preterm delivery are associated with improved survival in pregnant people with cancer.Retrospective population-based cohort study.Provinces of Alberta and Ontario, Canada, 2003-2016.Females aged 18-50 years diagnosed with cancer at <20 weeks' (for the assessment of procedural-induced abortion) or <37 weeks' gestation (for the assessment of provider-initiated delivery).Cox proportional hazard models assessed all-cause mortality in relation to procedural-induced abortion and provider-initiated preterm delivery, adjusting for cancer site, stage at diagnosis and age. Meta-analysis pooled the results across both provinces.All cause mortality.There were 512 pregnant people diagnosed with cancer at <20 weeks' gestation and 782 diagnosed with cancer at <37 weeks' gestation. Neither procedural-induced abortion (adjusted hazard ratio [aHR] = 1.39, 95% CI: 0.32-6.17) nor provider-initiated preterm delivery (aHR = 1.17, 95% CI: 0.76-1.81) were associated with improved survival following adjustment for age, stage at diagnosis and cancer site.Neither procedural-induced abortion nor provider-initiated preterm birth was associated with improved survival in pregnant people diagnosed with cancer; however, these obstetric interventions are highly personal decisions best decided by the pregnant person in consultation with their care providers.© 2024 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.