光疗法已经取得了长足的发展，因为在第二个近红外（NIR-II）窗口中，它具有更大的组织穿透性和更少的不良后果。在这项工作中，采用一锅水热法合成了一种特殊的 NIR-II 响应性铁掺杂碳纳米颗粒 (FDCN)，用于光热和化学动力学联合治疗。 FDCN 的介孔纳米结构的尺寸分布超过 225 nm，可实现有效的酸化。这些纳米颗粒释放的铁离子可以催化过氧化氢（H2O2）分解为羟基自由基（·OH），用于化学动力学治疗（CDT）。除了 CDT 用途外，FDCN 还可以有效吸收 1064 nm 光并将其转化为局部热量，实现 36.3% 的光热转换效率 (PCE)。这种双重功能不仅可以通过光热疗法（PTT）直接根除癌细胞，还可以增强化学动力学反应，产生协同效应，放大治疗效果。 FDCN 在细胞和动物试验中均表现出显着的抗癌活性，且不会产生重大的全身毒性。这表明该化合物在临床癌症治疗中具有广阔的应用前景。

Phototherapy has demonstrated substantial development because in the second near-infrared (NIR-II) window it has a larger tissue penetration and fewer adverse consequences. In this work, a particular kind of NIR-II responsive Fe-doped carbon nanoparticles (FDCNs) is synthesized using a one-pot hydrothermal method for combined photothermal and chemodynamic therapy. The mesoporous nanostructure of FDCN, which has a size distribution that exceeds 225 nm, allows for effective acidification. The iron ions released from these nanoparticles can catalyze the decomposition of hydrogen peroxide (H2O2) into hydroxyl radical (•OH) for chemodynamic therapy (CDT). In addition to their CDT utility, FDCN can effectively adsorb and transform 1064 nm light into local heat, achieving a photothermal conversion efficacy (PCE) of 36.3%. This dual functionality not only allows for the direct eradication of cancer cells through photothermal therapy (PTT) but also enhances the chemodynamic reaction, creating a synergistic effect that amplifies the therapeutic outcome. The FDCN has demonstrated remarkable anticancer activity in both cellular and animal tests without incurring major systemic toxicity. This suggests that the compound has great promise for use in clinical cancer therapy.