多形性胶质母细胞瘤（GBM）是一种侵袭性、弥漫性的胶质瘤，患者存活率最低。最近多种治疗的失败表明，同时针对多个靶标可能是克服 GBM 致癌的不同策略。癌基因和抑癌基因的正常功能需要维持正常的细胞过程，因此这些基因活性的任何缺陷都会操作相应的信号通路，从而启动致癌过程。长链非编码 RNA (lncRNA) 存在于细胞的细胞质或细胞核中，控制基因的转录和翻译。 LncRNA 执行多种功能，包括表观遗传改变、蛋白质修饰和稳定性、转录调节以及通过海绵 miRNA 竞争 miRNA 来调节 mRNA 翻译。各种致癌 lncRNA 的鉴定及其在脑癌中的多重作用使它们成为未来用作神经胶质瘤诊断、预后和治疗靶点的潜在候选者。这项研究重点介绍了多种致癌lncRNA，并根据胶质母细胞瘤中调控的靶基因将它们分类为不同的信号通路。

Glioblastoma multiforme (GBM) is an aggressive and diffuse type of glioma with the lowest survival rate in patients. The recent failure of multiple treatments suggests that targeting several targets at once may be a different strategy to overcome GBM carcinogenesis. Normal function of oncogenes and tumor suppressor genes need for the preservation of regular cellular processes, so any defects in these genes' activity, operate the corresponding signaling pathways, which initiate carcinogenic processes. Long non-coding RNAs (lncRNAs) that can be found in the cytoplasm or nucleus of the cells, control the transcription and translation of genes. LncRNAs perform a variety of functions, including epigenetic alteration, protein modification and stability, transcriptional regulation, and competition for miRNA that regulate mRNA translation through sponging miRNAs. Identification of various oncogenic lncRNAs and their multiple roles in brain cancers making them potential candidates for use as glioma diagnostic, prognostic, and therapeutic targets in the future. This study highlighted multiple oncogenic lncRNAs and classified them into different signaling pathways based on the regulated target genes in glioblastoma.