肺癌是全球范围内高度流行的癌症，其致癌过程是由多种病理事件的积累驱动的。近年来，表观遗传学作为肺癌发生的关键因素而得到了广泛的认可。表观遗传学包括 DNA 甲基化、组蛋白修饰、染色质重塑和 RNA 修饰等过程。这些途径导致遗传表型的持久改变，这对于肺癌的进展和生长至关重要。然而，表观遗传学在肺癌中的具体机制和作用仍需要进一步阐明。我们从Web of Science数据库中获取出版物，并应用严格的搜索方法对其进行筛选。最终，我们收集了被引用次数最高的 100 次的高质量出版物。数据通过各种文献计量工具进行处理和可视化。这100篇论文的引用次数不同，最低为491次，最多为6316次。平均每篇论文被引用1119次。共有 1056 名共同作者在 27 个国家 185 个机构的 59 种期刊上发表了这些论文。肺癌表观遗传学领域的高水平研究大多在发达国家进行，其中美国无论在论文数量还是学术影响力上均处于领先地位。 DNA甲基化的研究一直是该学科长期以来的研究重点。近年来，随着新一代测序技术的发展，非编码RNA相关研究已成为研究热点。未来的研究方向可能更多地集中在探索信使RNA和环状RNA的作用机制以及开发基于非编码RNA药物的靶向治疗策略。我们通过各种文献计量分析工具分析了100篇顶级肺癌和表观遗传学文献。本研究简要概述了先前研究的结果，预测了未来的研究方向，并提供了进一步调查的潜在途径。© 2024 作者。

Lung cancer is a highly prevalent cancer on a global scale and its oncogenic process is driven by the accumulation of multiple pathological events. Epigenetics has gained significant recognition in recent years as a crucial contributor to the development of lung cancer. Epigenetics include processes such as DNA methylation, histone modification, chromatin remodeling, and RNA modification. These pathways lead to enduring alterations in genetic phenotypes, which are crucial in the advancement and growth of lung cancer. However, the specific mechanisms and roles of epigenetics in lung cancer still need to be further elucidated.We obtained publications from the Web of Science databases and applied a rigorous search method to filter them. Ultimately, we gathered high-quality publications that had received the highest 100 number of citations. The data were processed and visualized by various bibliometric tools.The 100 papers had varying numbers of citations, with the lowest being 491 and the most being 6316. On average, each work received 1119 citations. A total of 1056 co-authors were involved in publishing these papers in 59 journals from 185 institutions in 27 countries. The majority of high-caliber research in the subject of lung cancer epigenetics is conducted in advanced countries, with the United States taking the lead in terms of both the quantity of articles produced and their academic influence. The study of DNA methylation has been a longstanding research priority in the discipline. With the development of next-generation sequencing technology in recent years, research related to non-coding RNA has become a research hotspot. Future research directions may focus more on exploring the mechanisms of action of messenger RNA and circular RNA and developing targeted treatment strategies based on non-coding RNA drugs.We analyzed 100 top lung cancer and epigenetics documents through various bibliometric analysis tools. This study provides a concise overview of the findings from prior research, anticipates future research directions, and offers potential avenues for additional investigation.© 2024 The Authors.