高危人乳头瘤病毒 (HR-HPV) 与不同类型癌症的发生有关，例如宫颈癌、头颈癌（包括口腔癌、喉癌和口咽癌）、外阴癌、阴道癌、阴茎癌和肛门癌。癌前病变进展为癌症取决于与宿主细胞和被 HPV 感染的不同上皮相关的因素，例如扁平上皮的基底细胞以及子宫颈和肛门中发现的鳞柱状转化区 (STZ) 的细胞运河，富含硫酸乙酰肝素蛋白聚糖和整合素样受体。另一方面，与病毒基因型、多种病毒感染、病毒载量、病毒持久性和整合类型相关的因素决定了病毒断裂模式和病毒整合到宿主细胞基因组中的位点（内含子、外显子、基因间区域），诱导肿瘤抑制基因功能丧失并增加癌基因表达。这篇综述描述了病毒整合的作用以及 HR-HPV 在不同类型组织中诱导的分子机制。本综述的目的是确定与整合事件在不同类型癌症癌前病变进展中的作用相关的常见因素。© 2024 作者。

High-risk human papillomavirus (HR-HPV) is associated with the development of different types of cancer, such as cervical, head and neck (including oral, laryngeal, and oropharyngeal), vulvar, vaginal, penile, and anal cancers. The progression of premalignant lesions to cancer depends on factors associated with the host cell and the different epithelia infected by HPV, such as basal cells of the flat epithelium and the cells of the squamocolumnar transformation zone (STZ) found in the uterine cervix and the anal canal, which is rich in heparan sulfate proteoglycans and integrin-like receptors. On the other hand, factors associated with the viral genotype, infection with multiple viruses, viral load, viral persistence, and type of integration determine the viral breakage pattern and the sites at which the virus integrates into the host cell genome (introns, exons, intergenic regions), inducing the loss of function of tumor suppressor genes and increasing oncogene expression. This review describes the role of viral integration and the molecular mechanisms induced by HR-HPV in different types of tissues. The purpose of this review is to identify the common factors associated with the role of integration events in the progression of premalignant lesions in different types of cancer.© 2024 The Authors.