本文综述了大黄炮制的发展及药理研究现状。总结了不同炮制方法对大黄活性成分、药理作用、毒性的影响以及不同炮制的临床应用情况，为大黄的进一步药理研究和临床应用提供参考。 Pubmed、Embase、国家科技图书馆、Web of science、CNKI、中国科技期刊数据库、SinoMed、中华人民共和国药典等数据库。搜索词包括“大黄”、“生大黄”、“酒大黄”、“熟大黄”、“大黄炭”、“草药加工”、“化合物”、“药理作用”、“炎症”、“胃肠道出血”、大黄炮制的历史记载可追溯到汉代，并不断创新。目前，中药使用的大黄种类已稳定为三种：掌叶大黄（Rheum palmatum L.）、唐古特大黄（Rheum tanguticum Maxim.ex Balf）。和大黄。常见的混合物包括生大黄、酒大黄、熟大黄和大黄炭。大黄的活性化合物具有排便、抗菌和抗炎特性、调节凝血、保护消化系统和抗肿瘤活性。以中医理论为指导，不同大黄配伍使用，可增强泻下消积、清热解毒、凉血止血、活血化瘀、利湿退黄等特效，从而达到治疗的目的。有效治疗多种疾病。这些混合物对疾病的治疗作用不仅体现在大黄活性成分的变化上，也体现在中药剂型的变化上。炮制在降低毒性方面也显示出优势。不同的炮制方法改变了大黄的活性成分，从而增强了其多种药理作用，满足了多种疾病的治疗需要。根据患者的具体情况选择合适的炮制方法，可以最大限度地发挥其药理特性，改善临床效果。版权所有 © 2024 Wen、Yan、Fan、Lu、Li、Fu、Wei。

This study reviews the development of rhubarb processing and the current status of pharmacological research. We summarized the effects of different processing methods on the active compounds, pharmacological effects, and toxicity of rhubarb, as well as the clinical application of different concoctions, providing reference for further pharmacological research and clinical application of rhubarb.A comprehensive literature review was conducted using databases such as Pubmed, Embase, National Science and Technology Library, Web of science, CNKI, China Science and Technology Journal Database, SinoMed, and the Pharmacopoeia of the People's Republic of China. Search terms included "rhubarb", "raw rhubarb", "wine rhubarb", "cooked rhubarb", "rhubarb charcoal", "herbal processing", "compounds", "pharmacological effects", "inflammation", "gastrointestinal bleeding", and "tumor".Historical records of rhubarb processing date back to the Han Dynasty, with continual innovations. Currently, the types of rhubarb used in traditional Chinese medicine have stabilized to three species: Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. and Rheum officinale Baill. Common concoctions include raw rhubarb, wine rhubarb, cooked rhubarb and rhubarb charcoal. The active compounds of rhubarb are known to defecation, exhibit antibacterial and anti-inflammatory properties, regulate coagulation, protect the digestive system, and possess anti-tumor activities. Guided by Chinese medicine theory, the use of different rhubarb concoctions can enhance specific effects such as purgation to eliminate accumulation, clearing heat and toxins, cooling blood to stop hemorrhages, activating blood circulation to remove blood stasis, and inducing dampness to descend jaundice, thereby effectively treating various diseases. The therapeutic impact of these concoctions on diseases reflects not only in the changes to the active compounds of rhubarb but also in the formulations of traditional Chinese medicine. Processing has also shown advantages in reducing toxicity.Different processing methods alter the active compounds of rhubarb, thereby enhancing its various pharmacological effects and meeting the therapeutic needs of diverse diseases. Selecting an appropriate processing method based on the patient's specific conditions can maximize its pharmacological properties and improve clinical outcomes.Copyright © 2024 Wen, Yan, Fan, Lu, Li, Fu and Wei.