间充质干细胞衍生的细胞外囊泡在关节疾病中的治疗作用和潜在机制。
Mesenchymal stem cell-derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms.
发表日期：2024 Sep
作者：
Jinhui Wu, Jiangyi Wu, Zheng Liu, Yunquan Gong, Daibo Feng, Wei Xiang, Shunzheng Fang, Ran Chen, Yaran Wu, Shu Huang, Yizhao Zhou, Ningning Liu, Hao Xu, Siru Zhou, Baorong Liu, Zhenhong Ni
来源：
Stem Cell Research & Therapy
摘要：
关节疾病极大地影响全球患者的日常生活和职业功能。然而，关节疾病的常规治疗方法存在疗效不理想、副作用大等局限性，需要探索更有效的治疗策略。间充质干细胞 (MSC) 衍生的 EV (MSC-EV) 在组织修复和再生方面表现出较高的治疗功效，且免疫原性和致瘤性较低。最近的研究表明，基于EV的疗法对骨关节炎、肌腱和韧带损伤、股骨头坏死和类风湿性关节炎等关节疾病具有相当大的治疗效果。本文综述了各类MSC-EV在上述关节疾病中的治疗潜力，总结了MSC-EV的具体生物学效应的机制，并讨论了基于MSC-EV的治疗方式的基础研究及其临床前景。翻译。总的来说，这篇综述深入了解了MSC-EV在关节疾病中的治疗效果及其潜在机制，这可能有利于基于MSC-EV的治疗的临床转化。本文的转化潜力：基于MSC-EV的无细胞疗法可以有效促进再生和组织修复。当用于治疗关节疾病时，MSC-EV在临床前研究中已表现出理想的治疗效果。这篇综述可能会补充基于 MSC-EV 的关节疾病治疗及其临床转化的进一步研究。© 2024 作者。
Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint diseases have several limitations, such as unsatisfatory efficacy and side effects, necessitating the exploration of more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have demonstrated high therapeutic efficacyin tissue repair and regeneration, with low immunogenicity and tumorigenicity. Recent studies have reported that EVs-based therapy has considerable therapeutic effects against joint diseases, including osteoarthritis, tendon and ligament injuries, femoral head osteonecrosis, and rheumatoid arthritis. Herein, we review the therapeutic potential of various types of MSC-EVs in the aforementioned joint diseases, summarise the mechanisms underlying specific biological effects of MSC-EVs, and discuss future prospects for basic research on MSC-EV-based therapeutic modalities and their clinical translation. In general, this review provides an in-depth understanding of the therapeutic effects of MSC-EVs in joint diseases, as well as the underlying mechanisms, which may be beneficial to the clinical translation of MSC-EV-based treatment. The translational potential of this article: MSC-EV-based cell-free therapy can effectively promote regeneration and tissue repair. When used to treat joint diseases, MSC-EVs have demonstrated desirable therapeutic effects in preclinical research. This review may supplement further research on MSC-EV-based treatment of joint diseases and its clinical translation.© 2024 The Authors.