肺癌是全球癌症相关死亡的主要原因。据信，90%以上的肺癌是由吸烟和空气污染造成的。还已知呼吸道病原体与肺癌的发生和发展有关。尽管肺部的细菌生物量低于肠道，但新的证据表明肺部栖息着多种微生物。然而，关于肺微生物群失调在肺癌进展中的作用的知识有限。在这篇综述中，我们总结了有关微生物组与肺癌之间关系的当前信息。目的是概述肺癌微生物群的核心组成，以及肺部微生物群的特定生态失调在肺癌进展和疾病治疗中的作用。© 2023 作者。

Lung cancer is the leading cause of cancer-related deaths worldwide. Tobacco smoking and air pollution are believed to be responsible for more than 90% of lung cancers. Respiratory pathogens are also known to be associated with the initiation and development of lung cancer. Despite the fact that the bacterial biomass in the lungs is lower than that in the intestinal tract, emerging evidence indicates that the lung is colonized by a diverse array of microbes. However, there is limited knowledge regarding the role of dysbiosis of the lung microbiota in the progression of lung cancer. In this review, we summarize the current information about the relationship between the microbiome and lung cancer. The objective is to provide an overview of the core composition of the microbiota in lung cancer as well as the role of specific dysbiosis of the lung microbiota in the progression of lung cancer and treatment of the disease.© 2023 The Authors.