细胞焦亡是一种由gasdermine (GSDM) 介导的程序性细胞死亡。 GSDM 的 N 端结构域在质膜上形成孔，导致细胞膜破裂和细胞内容物释放，导致炎症反应并介导热死亡。细胞焦亡在炎症性疾病和恶性肿瘤中发挥着重要作用。随着焦亡研究的深入，越来越多的研究表明焦亡通路能够调节结直肠癌的肿瘤微环境和抗肿瘤免疫，与结直肠癌的发生、发展、治疗和预后密切相关。本文旨在探讨焦亡的分子机制以及焦亡在结直肠癌（CRC）发生、发展、治疗及预后中的作用，为CRC的临床诊治提供思路。©作者(s) 2024百事登出版集团版权所有。

Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain of GSDMs forms pores in the plasma membrane, causing cell membrane rupture and the release of cell contents, leading to an inflammatory response and mediating pyrodeath. Pyroptosis plays an important role in inflammatory diseases and malignant tumors. With the further study of pyroptosis, an increasing number of studies have shown that the pyroptosis pathway can regulate the tumor microenvironment and antitumor immunity of colorectal cancer and is closely related to the occurrence, development, treatment and prognosis of colorectal cancer. This review aimed to explore the molecular mechanism of pyroptosis and the role of pyroptosis in the occurrence, development, treatment and prognosis of colorectal cancer (CRC) and to provide ideas for the clinical diagnosis and treatment of CRC.©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.