抑郁症与结直肠癌（CRC）密切相关。很少有文献计量分析系统地总结了该领域的研究热点和最新进展。通过对结直肠癌与抑郁症关系相关出版物的文献计量分析来确定研究现状和热点。有关结直肠癌患者抑郁症的文章收集自Web of Science核心合集。使用CiteSpace和VOSviewer软件对文献计量网络进行可视化。从2001年到2022年，Supportive Care in Cancer、美国、蒂尔堡大学和Mols是最具生产力和影响力的期刊、国家、机构和作者名称。关键词的共现聚类分析将生活质量、焦虑和心理压力置于视觉网络图的中心。对簇进行进一步聚类并研究相关作用机制，结果表明：（1）细胞因子对于结直肠癌抑郁障碍的发生和发展具有重要作用； (2) MicroRNA对于结直肠癌抑郁症的发生至关重要； (3)某些抗癌药物具有促抑郁活性； (4)选择性5-羟色胺再摄取抑制剂同时具有抗肿瘤和抗抑郁活性。癌症人群的生活质量和心理护理是重点课题。细胞因子和microRNA的作用、抗癌药物的促抑郁活性及其抗肿瘤特性值得深入研究。©作者2024。百世登出版集团有限公司出版。保留所有权利。

Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field.To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression.Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks.From 2001 to 2022, Supportive Care in Cancer, the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity.Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.