本研究的目的是评估氢在预防和治疗精神症状（特别是情绪低落和兴趣丧失）方面的潜力，并探讨其潜在机制。研究使用了表现出炎症衍生的抑郁症状的小鼠模型。癌症研究所的小鼠接受了为期 7 天的干预，每天通过摄入果冻摄入 30% 氢气或 40 克空气。最后一天，腹腔内给予脂多糖（LPS）5mg/kg，以诱导炎症相关的抑郁症状。 LPS 给药后 24 小时进行行为和生化评估。LPS 给药后，观察到自发行为减少；然而，在用氢气处理的组中，这种影响减轻了。社交互动测试显示，LPS 治疗组与不熟悉的小鼠的互动显着减少，而氢气治疗组则没有表现出这种减少。两组的强迫游泳测试均未发现显着变化。此外，在氢组中施用 LPS 不会导致 zonula occlusionns-1 的减少，这是一种与脑血管屏障屏障功能相关并在紧密连接中表达的生化标志物。氢施用显示出对 LPS 诱导的兴趣丧失，表明在症状预防中具有潜在作用。然而，在这个特定模型中，它并没有表现出对抑郁症状的抑制作用。这些发现强调了氢在炎症引起的精神症状中的微妙影响，表明了进一步探索和研究的潜在途径。© 2024 作者。约翰·威利 (John Wiley) 发表的精神病学和临床神经科学报告

The objective of this study was to evaluate the potential of hydrogen in preventing and treating psychiatric symptoms, particularly depressed mood and loss of interest, and to explore its underlying mechanisms. A mouse model exhibiting inflammation-derived depressive symptoms was used for the investigation.Institute of Cancer Research mice were subjected to a 7-day intervention of either 30% hydrogen or 40 g per day of air via jelly intake. On the final day, lipopolysaccharide (LPS) was intraperitoneally administered at 5 mg/kg to induce inflammation-related depressive symptoms. Behavioral and biochemical assessments were conducted 24 h post-LPS administration.Following LPS administration, a decrease in spontaneous behavior was observed; however, this effect was mitigated in the group treated with hydrogen. The social interaction test revealed a significant reduction in interactions with unfamiliar mice in the LPS-treated group, whereas the hydrogen-treated group exhibited no such decrease. No significant changes were noted in the forced-swim test for either group. Additionally, the administration of LPS in the hydrogen group did not result in a decrease in zonula occludens-1, a biochemical marker associated with barrier function at the cerebrovascular barrier and expressed in tight junctions.Hydrogen administration demonstrated a preventive effect against the LPS-induced loss of interest, suggesting a potential role in symptom prevention. However, it did not exhibit a suppressive effect on depressive symptoms in this particular model. These findings highlight the nuanced impact of hydrogen in the context of inflammation-induced psychiatric symptoms, indicating potential avenues for further exploration and research.© 2024 The authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.