呼吸道癌是全世界癌症相关死亡的主要原因，但东西方的统计数据有所不同。本研究旨在估计 1990 年至 2019 年亚洲、地区和国家层面气管癌、支气管癌、肺癌 (TBL) 和喉癌的负担及其可归因风险。使用 2019 年全球疾病负担、伤害和风险因素研究 (GBD) 数据库计算呼吸道癌症的残疾、寿命损失年数和残疾调整生命年 (DALY)。计算 1990 年至 2019 年 TBL 癌症的年龄标准化发病率，并根据吸烟和社会人口指数 (SDI) 进行调整。对33个亚洲国家因各危险因素导致的TBL癌和喉癌死亡人数进行了估计。2010年至2019年，亚洲TBL癌的年龄标准化发病率和死亡率有所下降，而喉癌的发病率有所上升。吸烟是导致 TBL 和喉癌死亡的主要特定危险因素。亚洲国家的 TBL 癌症负担受到 SDI 和吸烟的影响，特别是在中亚男性中。过去 30 年来，东亚地区的死亡人数、伤残调整生命年 (DALY) 和喉癌发病率没有显着变化，但男性和男女合计呈轻微下降趋势，而女性近年来呈上升趋势。亚洲 TBL 癌和喉癌的发病病例数和死亡人数。 SDI和吸烟是影响亚洲国家TBL癌症疾病负担的主要因素。这项研究强调需要制定量身定制的癌症控制计划，以解决亚洲不同国家呼吸道癌症的负担。© 2023 作者。由Elsevier B.V.代表中华医学会出版。

Respiratory cancer is the leading cause of cancer-related deaths worldwide, but its statistics vary between the East and West. This study aimed to estimate the burdens of tracheal, bronchus, and lung (TBL) cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia, and at regional and national levels.This research evaluated the incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) for respiratory tract cancers using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 database. Age-standardized rates were calculated for TBL cancer from 1990 to 2019, adjusted for smoking and socio-demographic index (SDI). Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019, while the incidence rate of larynx cancer increased. Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers. The burden of TBL cancer in Asian countries was influenced by SDI and smoking, particularly among males in Central Asia. Deaths, DALYs, and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years, but showed slight downward trends in males and both sexes combined, and an upward trend in females in recent years.The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia. SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries. This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries.© 2023 The Authors. Published by Elsevier B.V. on behalf of Chinese Medical Association.