心肌梗塞（MI）是发达国家全球首要死因，主要是由于动脉粥样硬化斑块生长和内皮损伤引起的冠状动脉血流量减少。虽然早期再灌注技术改善了预后，但长期治疗仍然很困难。 lncRNA的功能扩展到调节各种生理和病理条件下的基因表达，例如心血管疾病。本研究的目的是广泛评估称为转移相关肺腺癌转录物 1 (MALAT1) 的 lncRNA 在 MI 发生和治疗中的重要性。根据研究，MALAT1 与心血管系统的自噬、细胞凋亡、细胞增殖和炎症等过程有关。这项调查考察了最近的研究，该研究检查了 MALAT1 对心脏功能的影响及其作为诊断和治疗 MI 后并发症和缺血性再灌注损伤的手段的潜力。© 2024 Eshraghi、Sadati、Bahrami、Mirjalili、Farrokhian、Mahjoubin-Tehran 和 Mirzaei 。

Myocardial infarction (MI) stands at top global causes of death in developed countries, owing mostly to atherosclerotic plaque growth and endothelial injury-induced reduction in coronary blood flow. While early reperfusion techniques have improved outcomes, long-term treatment continues to be difficult. The function of lncRNAs extends to regulating gene expression in various conditions, both physiological and pathological, such as cardiovascular diseases. The objective of this research is to extensively evaluate the significance of the lncRNA called Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in the development and management of MI. According to research, MALAT1 is implicated in processes such as autophagy, apoptosis, cell proliferation, and inflammation in the cardiovascular system. This investigation examines recent research examining the effects of MALAT1 on heart function and its potential as a mean of diagnosis and treatment for post- MI complications and ischemic reperfusion injury.© 2024 Eshraghi, Sadati, Bahrami, Mirjalili, Farrokhian, Mahjoubin-Tehran and Mirzaei.