吸入百草枯 (PQ) 是世界上使用最广泛的除草剂之一，可能会导致肺损伤。姜黄 (Cl) 在传统和民间医学中具有悠久的历史，用于治疗包括呼吸系统疾病在内的多种疾病。本研究的目的是评估 Cl 对吸入 PQ 引起的大鼠肺损伤的预防作用。雄性Wistar大鼠被分为8组（n = 7），一组暴露于盐水（对照），其他组暴露于PQ气雾剂。在 PQ 暴露期间，给予盐水 (PQ)、Cl 提取物（两剂）、姜黄素 (Cu)、吡格列酮 (Pio) 以及 Cl-L Pio 和地塞米松 (Dex) 的组合。白细胞总数和分类计数、支气管肺泡灌洗液(BALF)中的氧化剂和抗氧化指标、肺组织中白细胞介素(IL)-10和肿瘤坏死α(TNF-α)水平、肺组织学病变评分、白细胞计数（总计数和分类计数）、丙二醛水平、气管反应性（TR）、IL-10、TNF-α和肺组织病理学变化均显着升高，但总硫醇含量和活性PQ 组 BALF 中过氧化氢酶和超氧化物歧化酶降低。与 PQ 组相比，两种剂量的 Cl、Cu、Pio、Cl-L Pio 和 Dex 均显着改善了所有测量变量。CI、Pio 和 Cl-L Pio 改善了 PQ 诱导的肺部炎症和氧化损伤，与效果相当Dex.© 2024 作者。约翰·威利出版的《免疫、炎症和疾病》

The inhalation of paraquat (PQ), one of the most widely used herbicides in the world, can result in lung injury. Curcuma longa (Cl) has long history in traditional and folk medicine for the treatment of a wide range of disorders including respiratory diseases.The aim of the present work was to evaluate the preventive effect of Cl on inhaled PQ-induced lung injury in rats.Male Wistar rats were divided into 8 groups (n = 7), one group exposed to saline (control) and other groups exposed to PQ aerosol. Saline (PQ), Cl extract, (two doses), curcumin (Cu), pioglitazone (Pio), and the combination of Cl-L + Pio and dexamethasone (Dex) were administered during the exposure period to PQ. Total and differential white blood cell (WBC) counts, oxidant and antioxidant indicators in the bronchoalveolar lavage (BALF), interleukin (IL)-10, and tumor necrosis alpha (TNF-α) levels in the lung tissues, lung histologic lesions score, and air way responsiveness to methacholine were evaluated.WBC counts (Total and differential), malondialdehyde level, tracheal responsiveness (TR), IL-10, TNF-α and histopathological changes of the lung were markedly elevated but total thiol content and the activities of catalase and superoxide dismutase were decreased in the BALF in the PQ group. Both doses of Cl, Cu, Pio, Cl-L + Pio, and Dex markedly improved all measured variables in comparison with the PQ group.CI, Pio, and Cl-L + Pio improved PQ-induced lung inflammation and oxidative damage comparable with the effects of Dex.© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.