既往研究表明，光动力疗法、光热疗法和化疗联合治疗肝细胞癌（HCC）非常有效。然而，由于缺乏高效、低毒的药物递送平台，该方法的临床应用受到阻碍。为了解决这个问题，我们开发了一种名为ZID@RM的新型仿生纳米载体平台，该平台利用巨噬细胞膜封装的ZIF8功能纳米颗粒并负载吲哚菁绿和阿霉素。仿生纳米载体平台具有良好的生物相容性，降低被巨噬细胞快速清除的风险，提高对肝癌细胞的靶向能力。在酸度和红外光的双重调节下，ZID@RM刺激HCC细胞内产生丰富的活性氧，诱导肿瘤细胞焦亡并促进损伤相关分子模式的释放以诱导免疫反应。未来，该技术平台有潜力通过利用患者自身的巨噬细胞膜创建有效的肿瘤治疗药物递送系统来提供个性化和改进的医疗保健。图形摘要方案1仿生纳米药物递送平台的合成示意图（ ZID@RM）及其在肿瘤成像引导联合治疗中的应用。© 2024。控释协会。

Previous studies have demonstrated that the combination of photodynamic therapy, photothermal therapy and chemotherapy is highly effective in treating hepatocellular carcinoma (HCC). However, the clinical application of this approach has been hindered by the lack of efficient and low-toxicity drug delivery platforms. To address this issue, we developed a novel biomimetic nanocarrier platform named ZID@RM, which utilizes ZIF8 functional nanoparticles encapsulated with macrophage membrane and loaded with indocyanine green and doxorubicin. The bionic nanocarrier platform has good biocompatibility, reducing the risk of rapid clearance by macrophages and improving the targeting ability for HCC cells. Under the dual regulation of acidity and infrared light, ZID@RM stimulated the generation of abundant reactive oxygen species within HCC cells, induced tumor cell pyroptosis and promoted the release of damage-associated molecular patterns to induce immune responses. In the future, this technology platform has the potential to provide personalized and improved healthcare by using patients' own macrophage membranes to create an efficient drug delivery system for tumor therapy.Graphical abstract Scheme 1 Schematic representation of the synthesis of a biomimetic nanomedicine delivery platform (ZID@RM) and its application in tumor imaging-guided combination therapy.© 2024. Controlled Release Society.