在美国，乳腺癌占所有女性癌症的 30%。巨细胞病毒（CMV）是一种终身感染的疱疹病毒，可能在乳腺癌中发挥作用。 CMV 不具有致癌性，但在乳腺肿瘤中检测到了病毒 DNA 和蛋白质，表明可能对肿瘤的发展有贡献。 CMV 编码 cmvIL-10，它是人细胞 IL-10 (cIL-10) 的同源物，具有有效的免疫抑制活性。我们研究了CMV感染、细胞因子和乳腺癌之间的关系。我们评估了患有良性乳腺疾病（n = 38）、原位癌（n = 41）、浸润性癌、无淋巴结的女性血浆中CMV血清状态和细胞因子水平受累（Inv/LN-；n = 41），以及侵袭性淋巴结受累（Inv/LN；n = 37）。百分之五十的患者样本（n = 79）为 CMV 血清阳性。 CMV 状态和诊断之间没有相关性 (p = 0.75)。对于 CMV 患者，侵袭性疾病中 CMV IgG 水平有较高的趋势 (p = 0.172)。与 Inv/LN 组和 Inv/LN 组相比，CMV 原位患者的 CmvIL-10 水平较高（p = 0.020）。同样，与 Inv/LN 组和 Inv/LN 组相比，CMV 原位患者的 cIL-10 水平较高（p=0.043）。 CMV- 患者的结果有很大不同，与良性、原位或 Inv/LN 患者相比，Inv/LN- 患者的 cIL-10 水平最高（p = 0.019）。非裔美国患者与 CMV 状态显着相关 (p = 0.001)，且 cmvIL-10 水平低于白人患者 (p = 0.046)。未观察到 CMV IgG 与诊断之间存在关联，但 CMV 感染会影响细胞因子的产生并导致细胞因子改变乳腺癌细胞因子谱。© 2024。作者。

Breast cancer accounts for 30% of all female cancers in the US. Cytomegalovirus (CMV), a herpesvirus that establishes lifelong infection, may play a role in breast cancer. CMV is not oncogenic, yet viral DNA and proteins have been detected in breast tumors, indicating possible contribution to tumor development. CMV encodes cmvIL-10, a homolog of human cellular IL-10 (cIL-10) with potent immunosuppressive activities. We investigated the relationship between CMV infection, cytokines, and breast cancer.We evaluated CMV serostatus and cytokine levels in plasma of women with benign breast disease (n = 38), in situ carcinoma (n = 41), invasive carcinoma, no lymph node involvement (Inv/LN-; n = 41), and invasive with lymph node involvement (Inv/LN+; n = 37).Fifty percent of the patient samples (n = 79) were CMV seropositive. There was no correlation between CMV status and diagnosis (p = 0.75). For CMV+ patients, there was a trend toward higher CMV IgG levels in invasive disease (p = 0.172). CmvIL-10 levels were higher in CMV+ in situ patients compared to the Inv/LN- and Inv/LN+ groups (p = 0.020). Similarly, cIL-10 levels were higher in CMV+ in situ patients compared to the Inv/LN- and Inv/LN+ groups (p = 0.043). The results were quite different in CMV- patients where cIL-10 levels were highest in Inv/LN- compared to benign, in situ, or Inv/LN+ (p = 0.019). African American patients were significantly associated with CMV+ status (p = 0.001) and had lower cmvIL-10 levels than Caucasian patients (p = 0.046).No association was observed between CMV IgG and diagnosis, but CMV infection influences cytokine production and contributes to altered cytokine profiles in breast cancer.© 2024. The Author(s).