本研究旨在探讨 L1 细胞粘附分子 (L1CAM) 在子宫内膜癌预后评估中的作用，子宫内膜癌在分子分类中被描述为没有特定的分子谱 (NSMP)。这是对2008年1月至2022年1月期间在研究中心接受子宫内膜癌诊断并接受手术的150名患者的回顾性评价。在评估L1CAM免疫组织化学染色时，根据肿瘤细胞的阳性百分比进行评分。因此，得分 0 = 0%，得分 1 = 1% 至 10%，得分 2 = >10% 至 50%，得分 3 = >50%。如果肿瘤细胞染色≥10%（分数2和3），则认为呈阳性。 L1CAM阳性患者的淋巴管间隙侵犯和淋巴结转移频率明显高于L1CAM阴性患者（P=0.013和P=0.007）。 L1CAM 表达与突变型 p53 密切相关 (P = 0.003)。 L1CAM 阳性患者的复发率显着较高（P = 0.001），总生存期和无进展生存期显着较低（两者均 P = 0.001）。 79例患者（52.7%）被纳入NSMP组。其中约 84.8% (n = 67) 为 L1CAM 阴性，其中 15.2% (n = 12) 为 L1CAM 阳性。 L1CAM 阳性的 NSMP 患者的复发率显着较高（P = 0.001），总生存期和无进展生存期显着较低（分别为 P = 0.002 和 P = 0.001）。这项研究表明，L1CAM 表达状态可能会增加子宫内膜癌的预后信息，特别是在 NSMP 亚组中。考虑到 L1CAM 的预后重要性，将其用作标志物可能会对减少预后异质性做出重大贡献，尤其是在 NSMP 亚组中。版权所有 © 2024，国际妇科病理学家协会。

This study aims to investigate the role of L1 cell adhesion molecule (L1CAM) in the prognostic assessment of endometrial cancers that have been depicted as having no specific molecular profile (NSMP) in molecular classification. This is a retrospective review of 150 patients who received the diagnosis of endometrial cancer and underwent surgery at the study center between January 2008 and January 2022. When evaluating L1CAM immunohistochemical staining, scoring was done according to the percentage of positivity in tumor cells. Accordingly, score 0 = 0%, score 1=1% to 10%, score 2 = >10% to 50% and score 3 = >50%. If the staining in tumor cells was ≥10% (scores 2 and 3), it was considered positive. The patients with L1CAM positivity had significantly more frequent lymphovascular space invasion and lymph node metastasis than patients with L1CAM negativity (P = 0.013 and P = 0.007). L1CAM expression was strongly associated with mutant p53 (P = 0.003). Recurrence was significantly higher (P = 0.001) and overall survival and progression-free survival were significantly lower in patients with L1CAM positivity (P = 0.001 for both). Seventy-nine patients (52.7%) were put into NSMP group. About 84.8% of them (n = 67) were L1CAM negative and 15.2% of them (n = 12) were L1CAM-positive. Recurrence was significantly higher (P = 0.001) and overall survival and progression-free survival were significantly lower in patients with NSMP who were positive for L1CAM (P = 0.002 and P = 0.001, respectively). This study demonstrates that L1CAM expression status may add prognostic information to endometrial cancer, particularly in the NSMP subgroup. Considering the prognostic importance of L1CAM, its use as a marker may make significant contributions to reducing prognostic heterogeneity, especially in the NSMP subgroup.Copyright © 2024 by the International Society of Gynecological Pathologists.