高级别（HGOC）和低级别卵巢癌（LGOC）是两种不同的恶性肿瘤，具有不同的生物学特征、治疗模式和预期寿命。然而，生活质量（QOL）、睡眠和抑郁症状的差异尚未按等级进行检查，也没有与这些症状相关的炎症特征。我们的目标是通过 OC 等级来表征 QOL 和生物标志物。参与者包括 HGOC (N = 578) 或 LGOC (N = 85) 患者。参与者在初次手术或新辅助化疗前完成了心理社会因素的基线评估，并贡献了唾液中的皮质醇和血液中的白介素 6 (IL-6) 定量。术中收集样本以量化肿瘤皮质醇。一般线性模型用于按年级检查生物和心理变量的差异。在基线时，LGOC 患者报告较少的抑郁症 (p = 0.018) 和睡眠障碍 (p = 0.014)，但抑郁情绪没有显着差异 (p = 0.11) ) 或 QOL (p = 0.51) 与 HGOC 患者相比，调整年龄和疾病阶段。与 HGOC 相比，LGOC 中的肿瘤皮质醇水平有较低的趋势 (p = 0.078)。诊断一年后，我们发现生活质量和疲劳显着改善，植物性抑郁和 IL-6 水平下降，无论级别如何。我们首次描述了 LGOC 患者的心理社会经历。尽管 LGOC 患者的疾病预后较好，但其出现情绪障碍的可能性与 HGOC 患者一样。肿瘤皮质醇存在分级差异的趋势。我们的研究结果强调需要解决低度和高度卵巢恶性肿瘤患者的健康问题。版权所有 © 2024 Elsevier Inc. 保留所有权利。

High-grade (HGOC) and low-grade ovarian carcinoma (LGOC) are distinct malignancies with different biological features, treatment paradigms, and life expectancies. However, differences in quality of life (QOL), sleep, and depressive symptoms have not been examined by grade, and neither have inflammatory profiles associated with these symptoms. We aim to characterize QOL and biomarkers by OC grade.Participants included patients with HGOC (N = 578) or LGOC (N = 85). Participants completed baseline assessments of psychosocial factors prior to primary surgery or neoadjuvant chemotherapy and contributed saliva for cortisol and blood for interleukin-6 (IL-6) quantification. Samples were collected intraoperatively to quantify tumor cortisol. General linear models were used to examine differences in biological and psychological variables by grade.At baseline, patients with LGOC reported less depression (p = 0.018) and sleep disturbances (p = 0.014), but no significant difference in depressive mood (p = 0.11) or QOL (p = 0.51) compared to patients with HGOC, adjusting for age and disease stage. There were trends towards lower tumor cortisol levels (p = 0.078) in LGOC compared to HGOC. One-year post-diagnosis, we found a significant improvement in QOL and fatigue, and a decrease in vegetative depression and IL-6 levels irrespective of grade.We present the first characterization of psychosocial experiences of patients with LGOC. Despite having a better disease prognosis, patients with LGOC were just as likely to have mood disturbances as those with HGOC. There was a trend towards differences in tumor cortisol by grade. Our findings highlight the need to address well-being in patients with both low- and high-grade ovarian malignancies.Copyright © 2024 Elsevier Inc. All rights reserved.