自然杀伤/T细胞淋巴瘤（NKTCL）是一种起源于NK或T细胞的恶性肿瘤，具有高度侵袭性和异质性。 NKTCL 主要与 Epstein-Barr 病毒感染有关，对亚洲和拉丁美洲人群的影响尤为严重。由于天冬酰胺酶和免疫疗法的应用，临床结果显着改善。然而，对于一线治疗失败的患者来说，预后极差。多药耐药基因的过度表达、信号通路异常、表观遗传修饰和活跃的 Epstein-Barr 病毒感染可能是耐药性的原因。本综述总结了 NKTCL 的耐药机制并提出了潜在的治疗方法。版权所有 © 2024 The Chinese Medical Association，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 许可制作。

Natural killer/T cell lymphoma (NKTCL) is a malignant tumor originating from NK or T cells, characterized by its highly aggressive and heterogeneous nature. NKTCL is predominantly associated with Epstein-Barr virus infection, disproportionately affecting Asian and Latin American populations. Owing to the application of asparaginase and immunotherapy, clinical outcomes have improved significantly. However, for patients in whom first-line treatment fails, the prognosis is exceedingly poor. Overexpression of multidrug resistance genes, abnormal signaling pathways, epigenetic modifications and active Epstein-Barr virus infection may be responsible for resistance. This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.