众所周知，痛风是一种因尿酸盐结晶沉积在关节而影响人体健康和状态的代谢性疾病。人类正在从植物中寻找安全、成本低、对健康有效的自然疗法。芥子酸 (SA) 存在于植物中，并用作人类饮食中的植物成分。 SA具有很强的抗氧化活性、骨再生、抗癌、抗过敏、抗糖尿病作用。目前的研究旨在证实 SA 对单钠尿酸盐晶体 (MSU) 诱导的小鼠痛风性关节炎的抗痛风潜力。通过在后爪中施用秋水仙碱和MSU来进行阳性痛风性关节炎。在注射 MSU 前一小时（关节内注射 100 μg/kg），给阴性和阳性 MSU 关节炎小鼠口服 SA，剂量为 25 和 50 mg/kg。实验结束时，取样进行血清、组织病理学、氧化应激和基因表达分析。结果显示，SA显着恢复了关节水肿并恢复了MSU晶体——显示出组织病理学变化。在阳性关节炎小鼠中，细胞因子的产生、白细胞募集、氧化应激以及核苷酸结合域、富含亮氨酸家族、含有吡啶域的 3 (NLRP3) 炎性体基因的表达增加，并通过 SA 给药显着改善。此外，SA 对小鼠气囊模型显示出改善作用，据报道，炎症相关血细胞、促炎细胞因子和其他转录基因的表达下调。总之，芥子酸显示出对痛风性关节炎伴随副作用的潜在治疗用途，并且是对抗炎症相关疾病的良好补充剂。© 作者 2024。由牛津大学出版社出版。版权所有。如需权限，请发送电子邮件至：journals.permissions@oup.com。

As known, gout a metabolic disease due to the urate crystals deposition in the joints and affect human health and state. Humans are looking for safe natural remedies from plants with safe, low cost and high effect on their health. Sinapic acid (SA) is found in plants and used as phytoconstituent in human diets. SA has strong antioxidant activity, bone-regenerative, anti-cancer, anti-allergic, and antidiabetic effects. The current study was outlined to confirm the anti-gout potential of SA against monosodium urate crystals (MSU)-induced gouty arthritis in mice. Positive gouty arthritis was conducted by administration of colchicine and MSU in the hind paw. SA was orally administered to negative and positive MSU arthritic mice at 25 and 50 mg/kg, one-hour before MSU injection (100 μg/kg intra-articular). At the end of the experiment, sampling was done for serum, histopathology, oxidative stress and gene expression analysis. The results showed that SA significantly recovered the joint edema and recovered MSU crystals-showed histopathological changes. The production of cytokines, leukocyte recruitment, oxidative stress, and nucleotide-binding domain, leucinerich-containing family, pyrin domain-containing-3 (NLRP3)-inflammasome genes expressions were increased in positive arthritic mice and ameliorated significantly by SA administration. Moreover, SA showed ameliorative impacts on air pouch model of mice as reported by the down regulation in the expression of inflammation related blood cells, proinflammatory cytokines and other transcriptional genes. In conclusion, sinapic acid showed a potential therapeutic use against side effects accompanying gouty arthritis and is good as a supplement against inflammation associated disorders.© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.