支持基因型定制治疗选择的精准肿瘤学平台。
A Precision Oncology Platform to Support Genotype-Tailored Therapy Selection.
发表日期：2024 Aug 22
作者：
Taxiarchis Botsis, Jonathan Spiker, Kory Kreimeyer, Maria Fatteh, Jamie Wehr, Mimi Najjar, Jessica Tao, Rena Xian, Nicole L Imamovic, Ander Pindzola, Adrian Dobs, Jenna Canzoniero, Valsamo Anagnostou
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
由于当前的方法在整合不同分子数据源方面面临挑战，因此迫切需要简化流程来识别有资格参加临床试验和/或靶向治疗的基因型匹配个体。我们开发了一个精准肿瘤学平台，帮助分子肿瘤委员会和社区肿瘤学家审查患者的表型、评估相关知识并确定基因型匹配的治疗方法。
There is a critical need for a streamlined process to identify genotype-matched individuals eligible for enrollment into clinical trials and/or targeted therapies, as current methodologies face challenges in integrating diverse molecular data sources. We have developed a precision oncology platform to assist molecular tumor boards and community oncologists in reviewing patients' phenotypes, evaluating related knowledge, and identifying genotype-matched therapies.