立体定向放射外科 (SRS) 代表了颈静脉孔神经鞘瘤 (JFS) 的微创且有价值的替代方案，既可以作为前期治疗也可以作为辅助治疗（采用混合方法）。我们对洛桑大学医院 (CHUV) 治疗的病例进行了回顾性审查）从 2010 年 6 月到 2023 年 10 月。11 名患者接受了 SRS，其中 3 名患者之前接受过手术，其中 2 名在我们中心按照计划的联合方法进行手术，1 名患者在另一个中心接受手术。两名患者接受了“体积分期”SRS。 SRS 的平均年龄为 60 岁（中位数 68 岁；范围 29-83 岁）。六名患者出现颅神经 (CN) 症状，五名患者无症状。 SRS 的平均肿瘤体积为 2.1 cc（中位数 1.2；范围 0.068-7.3 cc），所有病例的边缘剂量均为 12 Gy。平均随访期为 3.9 年（中位数 2，范围 1-7）。 6 名患者接受 SRS 治疗后，脑神经功能得到改善，另外 5 名患者保持稳定。在最后一次随访中，除一名患者在 SRS 后 18 个月接受手术外，所有肿瘤均显示体积减小，在 6 个月和 12 个月时体积增加，并进一步出现第十二个 CN 麻痹和延髓受压。尽管肿瘤在 18 个月时有所缩小，但该患者仍需要显微手术切除以维持症状并得到进一步控制。 SRS 后 1 年的平均肿瘤体积为 1.6 cc（中位数 0.55；范围 0.028-7.77 cc），2 年时为 1.31 cc（中位数 0.76；范围 0.19-5），3 年时为 1.32 cc（中位数 0.59） ；范围0.23-4.8）。未观察到不良放射事件。立体定向放射外科被认为是治疗颈静脉孔神经鞘瘤的安全有效的方法，可确保所有患者的肿瘤长期得到高控制率。 6 名有缺陷的患者在 SRS 后脑神经功能得到改善，另外 5 名无缺陷的患者仍然无症状。对于较大的肿瘤，组合/混合方法可能是一种有价值的替代方案，可以控制肿瘤并保留神经功能。© 2024。作者。

Stereotactic radiosurgery (SRS) represents a minimally invasive and valuable alternative for jugular foramen schwannomas (JFS), both as upfront and/or adjuvant treatment (in hybrid approaches).We conducted a retrospective review of our cases treated at the Lausanne University Hospital (CHUV) from June 2010 to October 2023. Eleven patients underwent SRS, among whom three had prior surgery, two in our center in the frame of a planned combined approach and one in another center. Two patients received "volume-staged" SRS. The mean age at SRS was 60 years (median 68; range 29-83). Cranial nerve (CN) symptoms were present in six patients, while five were asymptomatic. The mean tumor volume at SRS was 2.1 cc (median 1.2; range 0.068-7.3 cc), with a 12 Gy marginal dose prescribed in all cases.The mean follow-up period was 3.9 years (median 2, range 1-7). Cranial nerve function improved after SRS in six patients, while five remained stable. At the last follow-up, all tumors showed a decrease in volume, except for one patient, who underwent surgery at 18 months after SRS, for volumetric increase at 6 and 12 months, with further XII-th CN palsy and medulla oblongata compression. Although tumor decreased at 18 months, such patient needed microsurgical resection for symptom persistence and was further controlled. The mean tumor volume at 1 year post-SRS was 1.6 cc (median 0.55; range 0.028-7.77 cc), at 2 years was 1.31 cc (median 0.76; range 0.19-5), and at 3 years was 1.32 cc (median 0.59; range 0.23-4.8). No adverse radiation events were observed.Stereotactic radiosurgery is considered a safe and effective treatment for jugular foramen schwannomas, ensuring high rates of tumor control in all patients over the long term. The cranial nerve function improved after SRS in the 6 patients who had deficits and the other 5 patients who had no deficits remained asymptomatic. For larger tumors, combined/hybrid approaches can be a valuable alternative, to obtain tumor control and to preserve neurological function.© 2024. The Author(s).