乳房植入物相关的间变性大细胞淋巴瘤（BIA-ALCL）是一种罕见的恶性肿瘤。许多 BIA-ALCL 病例是根据迟发性积液和/或肿块的存在来识别的。重要的是，美国食品和药物管理局指出，在所有诊断为带纹理植入物的患者的病例中，患者要么有光滑和纹理装置混合植入的病史，要么没有提供临床病史供审查。在日本，2019年报道了第一例BIA-ALCL，我们在2021年12月在日本遇到了第三例。此前在日本学术会议（日本肿瘤整形乳腺外科协会）上报道的BIA-ALCL总共有5例学会http://jopbs.umin.jp/medical/index.html），其中仅发布了第一个案例。与第一例不同的是，该患者的临床特征高度提示乳腺癌术后胸壁复发，皮肤上有肿块和皮疹。该患者是一名45岁女性，曾接受乳房再造术后8 年前接受过右乳房癌症手术。该患者在乳房下区域出现肿块和皮疹，我们怀疑硅胶乳房植入物 (SBI) 受损或胸壁复发。我们通过空芯针活检检查了肿块，并做出了 BIA-ALCL 的病理诊断。影像学结果提示胸廓内淋巴结肿胀，淋巴瘤浸润超出包膜，但无转移灶（cStage III）。 SBI和淋巴瘤整块切除后，进行辅助全身治疗。我们遇到了日本第三例BIA-ALCL。这是一个临床晚期病例；然而，BIA-ALCL 被发现已缓解。© 2024。作者。

Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare malignancy. Many cases of BIA-ALCL are identified based on the presence of late-onset effusion and/or masses. Importantly, the United States Food and Drug Administration noted that in all cases diagnosed in patients with textured implants, the patients either had a history of mixed implantation of smooth and textured devices or no clinical history was supplied for review. In Japan, the first case of BIA-ALCL was reported in 2019, and we encountered the third case in Japan in December 2021. There have been a total of five cases of BIA-ALCL previously reported at Japanese academic conferences (Japan Oncoplastic Breast Surgery Society. http://jopbs.umin.jp/medical/index.html ), of which only the first case has been published. Unlike the first case, this patient had clinical features that were highly suggestive of the postoperative chest wall recurrence of breast cancer, with a mass and rash on the skin.The patient was a 45-year-old woman who had undergone breast reconstruction after breast cancer surgery of the right breast 8 years previously. The patient presented with a mass and skin rash inside the inframammary area, and we suspected a damaged silicone breast implant (SBI) or chest wall recurrence. We examined the mass by a core needle biopsy and made a pathological diagnosis of BIA-ALCL. Imaging findings suggested internal thoracic lymph node swelling and lymphoma infiltration beyond the capsule but no metastatic lesions (cStage III). After en bloc resection of the SBI and lymphoma, adjuvant systemic therapy was performed.We encountered the third case of BIA-ALCL in Japan. This was a case with clinically advanced stage of disease; however, the BIA-ALCL was found to be in remission.© 2024. The Author(s).