受皮肤癌影响的有色人种 (POC) 的发病率和死亡率更高。尽管皮肤癌总体上最常发生在白人中，但皮肤 T 细胞淋巴瘤 (CTCL) 是一个例外。 CTCL 是一种罕见的皮肤癌，包含非霍奇金淋巴瘤的几种亚型；每个都包含因种族而异的独特临床特征。我们的目的是回顾和汇编黑人、亚裔或太平洋岛民 (API) 和西班牙裔患者 CTCL 亚型的流行病学、临床表现、治疗和结果方面的差异。目前的文献支持 CTCL 过程中存在因种族而异的细微差别。多项研究表明，发病率存在种族差异，其中黑人患者的发病率最高。 CTCL 的皮肤表现在 POC 中差异很大，并且临床 CTCL 变异的偏好通常因种族以及皮肤受累 (BSA) 的严重程度而异。 POC 之间对治疗的反应和治疗类型也不同，部分原因可能是某些种族经历的不同 CTCL 亚型。预后因素往往因种族而异，尽管黑人患者的预后始终较差，而 API 患者的预后可能较好。目前，尚无明确的结论来解释彩色患者 CTCL 皮肤中观察到的差异，但生物和社会经济因素已被认为是潜在的驱动因素。由于 POC 在我们人口中所占的比例越来越大，因此必须有足够的医生意识和对 CTCL 种族细微差别的了解，才能开始解决这些差异。© 作者 2024。由牛津大学出版社代表英国皮肤科医师协会出版。

People of color (POC) affected by skin cancer suffer disproportionately from worse morbidity and mortality. Although skin cancers occur most frequently in White individuals overall, cutaneous T-cell lymphoma (CTCL) is an exception. CTCL is a rare skin cancer comprising several subtypes of non-Hodgkin lymphoma; each contains a unique clinical profile that varies with race. Our aim is to review and compile the differences in epidemiology, clinical presentation, treatments, and outcomes of the CTCL subtypes in Black, Asian or Pacific-Islander (API), and Hispanic patients. The current literature supports that there are nuances in the course of CTCL that differ with race. Across multiple studies, racial differences in incidence patterns have been reported, with the highest rates among Black patients. Cutaneous manifestation of CTCL are highly variable in POC, and the predilection for clinical CTCL variants often differs with race, as well as severity of cutaneous involvement (BSA). Response to and type of treatment also differs among POC, and may be partially attributable to the varying CTCL subtypes experienced by certain races. Prognostic factors tend to vary with race, although Black patients consistently experience poor outcomes, while API patients may have a more favorable prognosis. Currently, there is no definitive conclusion to account for differences observed in CTCL skin of color patients, however biologic and socioeconomic factors have been proposed as potential drivers. As POC comprise an increasing portion of our population, adequate physician awareness and knowledge of racial nuances in CTCL are necessary to begin addressing these disparities.© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.