氟喹诺酮类药物是最常用的抗生素。由于已知它们会导致抗菌药物耐药性，因此需要对它们的处方模式进行更多限制。本研究旨在描述氟喹诺酮处方的临床实践、肾功能不全患者的剂量调整和细菌耐药性概况，最终提供基于证据的建议，以优化当地人群的抗生素处方实践。这项回顾性横断面研究是在An -巴勒斯坦纳贾国立大学医院。数据收集自 2021 年 7 月至 2023 年 6 月期间接受环丙沙星或左氧氟沙星治疗的住院患者。检查了医院各科室 692 名住院患者的数据（左氧氟沙星 409 名，环丙沙星 283 名）。通过 IBM SPSS 23.0 版进行统计分析，总结人口统计、临床和流行病学数据。社会人口学概况显示不同的年龄分布，环丙沙星和左氧氟沙星分别有 25.4% 和 39% 的年龄超过 50 岁。环丙沙星主要用于肿瘤科（28.2%），手术预防（22.6%）和发热或无发热中性粒细胞减少症（21.1%）是最常见的适应症。左氧氟沙星主要在内科病房使用（45.7%），主要用于下呼吸道感染（58.8%）和骨髓移植的预防（16.5%）。肠球菌和耐甲氧西林金黄色葡萄球菌是最常见的分离病原体，其中 62.5% 的分离株对环丙沙星具有耐药性。此外，产生超广谱 β-内酰胺酶的肠杆菌是最常见的分离病原体，其中 33.3% 对左氧氟沙星具有耐药性。统计分析显示抗生素的选择和治疗方法之间存在显着关联。左氧氟沙星明显比环丙沙星更有可能被用作经验性治疗 (p < 0.001)，而环丙沙星更有可能被用作靶向治疗 (p< 0.001)。 这项研究调查了大范围患者的处方实践以及对左氧氟沙星和环丙沙星的耐药性。发展中国家的医院。根据细菌耐药性概况，我们得出结论，医院部门需要对这些抗生素的使用施加更大的限制。为此，应根据现行治疗指南进一步研究氟喹诺酮类药物的临床疗效，以评估其适当性。© 2024。作者。

Fluoroquinolones are the most commonly prescribed antibiotics. Because of their known tendency to drive antimicrobial resistance, their prescribing patterns need to be more restricted. This study aimed to describe the clinical practice of fluoroquinolone prescription, dose adjustments for renal impairment patients and bacterial resistance profiles, eventually providing evidence-based recommendations to optimize antibiotic prescribing practices in the local population.This retrospective, cross-sectional study was conducted at An-Najah National University Hospital in Palestine. The data were collected from admitted patients who were given ciprofloxacin or levofloxacin from July 2021 to June 2023. Data from 692 inpatients across various hospital departments were examined (409 for levofloxacin and 283 for ciprofloxacin). Statistical analysis was performed via IBM SPSS version 23.0 to summarize the demographic, clinical, and epidemiological data.The sociodemographic profile revealed diverse age distributions, with 25.4% and 39% older than 50 years for ciprofloxacin and levofloxacin, respectively. Ciprofloxacin was predominantly used in the oncology department (28.2%), with surgical prophylaxis (22.6%) and febrile or afebrile neutropenia (21.1%) being the most common indications. Levofloxacin was predominantly used in the medical ward (45.7%), mainly for lower respiratory tract infection (58.8%) and prophylaxis for bone marrow transplantation (16.5%). Enterococcus and methicillin-resistant Staphylococcus aureus were the most commonly isolated pathogens, with 62.5% of the isolates demonstrating resistance to ciprofloxacin. Moreover, extended-spectrum beta-lactamase-producing Enterobacterales were the most common pathogen isolated, with 33.3% being resistant to levofloxacin. Statistical analysis revealed a significant association between the choice of antibiotic and the approach to therapy. Levofloxacin was significantly more likely than ciprofloxacin to be used as empiric therapy (p < 0.001), whereas ciprofloxacin was more likely to be used as targeted therapy (p < 0.001).This study investigated prescribing practices and resistance to levofloxacin and ciprofloxacin in a large hospital in a developing country. According to the bacterial resistance profiles, we conclude that there is a need for hospital departments to exercise greater restraint on the use of these antibiotics. To this end, further studies addressing the clinical efficacy of fluoroquinolones against the current treatment guidelines to evaluate their appropriateness should be carried out.© 2024. The Author(s).