牙关紧闭是头颈癌患者进行治疗性放射治疗后可能出现的严重并发症。然而，在这种情况下，有关这种副作用的证据仍有待完全定义，特别是在剂量测定参数方面。关键参考文献来自 PubMed 查询。还使用了手动搜索和 ClinicalTrials.gov。本文包含一份叙述性报告，并对文献中有关辐射引起的牙关紧闭的证据进行了批判性讨论，特别是剂量学问题。治疗目标应该是保持高治愈率并限制并发症的发生。有必要对剂量测量和临床结果进行进一步评估，以确定风险较高的患者，从而进行针对性治疗调整。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Trismus is a potentially critical morbidity following curative-intended radiotherapy in head and neck cancer patients. However, in this setting, evidence regarding this side effect remains to be fully defined, particularly in terms of dosimetric parameters.Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used.This paper contains a narrative report and a critical discussion of the evidence on radiation-induced trismus in the literature, particularly the dosimetric concerns.The treatment goal should be to maintain high cure rates and limit the onset of complications. Further evaluations of dosimetric measures and clinical outcomes are warranted to identify patients at higher risk to target treatment tailoring.Copyright © 2024 Elsevier B.V. All rights reserved.