研究动态
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基于二维二硫化钼的多模式癌症治疗学的最新进展。

Recent developments in two-dimensional molybdenum disulfide-based multimodal cancer theranostics.

发表日期:2024 Aug 28
作者: Xinbo Yu, Chen Xu, Jingxu Sun, Hainan Xu, Hanwei Huang, Ziyang Gan, Antony George, Sihui Ouyang, Funan Liu
来源: JOURNAL OF NANOBIOTECHNOLOGY

摘要:

癌症研究的最新进展导致了创新纳米材料的产生,以改进诊断和治疗策略。尽管二维 (2D) 二硫化钼 (MoS2) 作为生物医学应用中的多功能平台已被证明具有潜力,但很少有评论文章关注基于 MoS2 的癌症治疗诊断平台。本综述旨在通过全面概述 2D MoS2 癌症治疗诊断学的最新发展以及该领域的新兴策略来填补这一空白。本综述重点介绍了 2D MoS2 在单模型成像和治疗中的潜在应用,包括荧光成像、光声成像、光热治疗和催化治疗。本综述进一步对 2D MoS2 在诊断和协同治疗平台多模态成像中的潜力进行了分类。特别是,这篇综述强调了 2D MoS2 作为集成药物递送系统的进展,涵盖从化疗和基因治疗到免疫治疗和光动力治疗的广泛治疗策略。最后,本综述讨论了满足先进癌症诊断和治疗诊断应用的多样化需求的当前挑战和未来前景。© 2024。作者。
Recent advancements in cancer research have led to the generation of innovative nanomaterials for improved diagnostic and therapeutic strategies. Despite the proven potential of two-dimensional (2D) molybdenum disulfide (MoS2) as a versatile platform in biomedical applications, few review articles have focused on MoS2-based platforms for cancer theranostics. This review aims to fill this gap by providing a comprehensive overview of the latest developments in 2D MoS2 cancer theranostics and emerging strategies in this field. This review highlights the potential applications of 2D MoS2 in single-model imaging and therapy, including fluorescence imaging, photoacoustic imaging, photothermal therapy, and catalytic therapy. This review further classifies the potential of 2D MoS2 in multimodal imaging for diagnostic and synergistic theranostic platforms. In particular, this review underscores the progress of 2D MoS2 as an integrated drug delivery system, covering a broad spectrum of therapeutic strategies from chemotherapy and gene therapy to immunotherapy and photodynamic therapy. Finally, this review discusses the current challenges and future perspectives in meeting the diverse demands of advanced cancer diagnostic and theranostic applications.© 2024. The Author(s).