阿霉素（DOX）是一种有效的化疗药物，用于治疗多种类型的癌症，但其临床应用受到心脏毒性的限制，主要是由于氧化应激。姜黄素（CUR）是一种天然多酚化合物，具有很强的抗氧化特性，但其对 DOX 引起的心脏毒性的潜在保护作用需要进一步研究。本研究旨在评估 CUR 在减轻 DOX 诱导的 BALB/c 小鼠心脏氧化应激方面的功效。小鼠接受 9 mg/kg 或 16 mg/kg 剂量的 DOX；一半的小鼠每天接受 100 mg/kg CUR 剂量，持续 15 天。通过评估生存分析、组织病理学检查和氧化应激标志物来确定 CUR 的心脏保护作用。结果表明，CUR 显着减少氧化损伤并提高生存率，特别是在较低的 DOX 剂量（9 毫克/千克）下。使用 DOX-9 mg/kg 加 CUR 治疗的小鼠表现出健康状况改善，活性氧 (ROS)、脂质过氧化、巯基产生和蛋白质羰基化水平降低。组织病理学分析证实心脏组织损伤减少。总之，CUR 与较低剂量的 DOX 联合有效减少氧化应激和心脏损伤，提高 BALB/c 小鼠的存活率。这些发现表明，CUR 是一种有前途的辅助疗法，可减轻 DOX 引起的心脏毒性，有可能提高 DOX 在癌症治疗中的治疗指数。

Doxorubicin (DOX) is a potent chemotherapeutic agent used to treat multiple types of cancer, but its clinical application is limited by cardiotoxicity, mainly due to oxidative stress. Curcumin (CUR) is a natural polyphenolic compound with strong antioxidant properties, but its potential protective effects against DOX-induced cardiotoxicity need further investigation. This study aimed to evaluate CUR's efficacy in mitigating DOX-induced oxidative stress in the hearts of BALB/c mice. Mice received a DOX dose of 9 mg/kg or 16 mg/kg; half of the mice received daily doses of 100 mg/kg CUR for 15 days. Survival analysis, histopathological examination, and oxidative stress markers were assessed to determine the cardioprotective effects of CUR. Results showed that CUR significantly reduced oxidative damage and improved survival rates, particularly at the lower DOX dose (9 mg/kg). Mice treated with DOX-9 mg/kg plus CUR showed improved health conditions and reduced levels of reactive oxygen species (ROS), lipid peroxidation, sulfhydryl production, and protein carbonylation. Histopathological analysis confirmed reduced cardiac tissue damage. In conclusion, CUR combined with a lower dose of DOX effectively reduces oxidative stress and cardiac injury, enhancing survival in BALB/c mice. These findings suggest that CUR is a promising adjunct therapy to mitigate DOX-induced cardiotoxicity, potentially improving the DOX therapeutic index in cancer treatment.