开发新型多峰纳米材料抗癌药物以满足复杂的临床需求是一项紧迫的挑战。本研究提出了一种新型均匀中空掺硫镍铜铁普鲁士蓝类似物（NiCuFe-S），其具有令人满意的尺寸和性能，可作为抗癌剂，通过简单且环保的程序进行有效的宫颈癌治疗。通过不同的光谱和显微方法对 NiCuFe-S 进行了表征和讨论。此外，为了证明NiCuFe-S的抗癌能力，进行了体外和体内实验。与未掺杂的NiCuFe相比，NiCuFe-S由于电子带隙变窄而表现出显着增强的光热和催化活性效应以及S掺杂导致的电子电路路径增加。 NiCuFe-S的中空结构有利于装载小分子药物，例如阿霉素（DOX），将其转变为用于宫颈癌治疗的多模式纳米平台。体外和体内实验证明了NiCuFe-S纳米治疗剂在化学动力学疗法（CDT）、光热疗法（PTT）和宫颈癌化疗中的潜力。这项研究不仅克服了固有的局限性，而且显着拓宽了普鲁士的应用范围。生物医学中的蓝色类似物。© 2024 Xu 等人。

Developing novel multimodal nanomaterials-based anticancer agents to meet complex clinical demands is an urgent challenge. This study presents a novel uniform hollow S-doped NiCuFe Prussian blue analogue (NiCuFe-S) with satisfactory size and properties as anticancer agents for efficient cervical cancer therapy using a simple and environmentally friendly procedure.The formation mechanism and the reason for enhanced performance of NiCuFe-S were characterized and discussed by diverse spectroscopic and microscopic methods. Moreover, to demonstrate the anti-cancer ability of NiCuFe-S, in vitro and in vivo experiments were carried out.Compared to the non-doped NiCuFe, the NiCuFe-S exhibited significantly enhanced photothermal and catalytic activity attributed to the electronic bandgap-narrowing effect and the increased electron circuit paths resulting from S doping. The hollow structure of NiCuFe-S facilitated the loading of small-molecule drugs, such as doxorubicin (DOX), transforming it into a multimodal nanoplatform for cervical cancer treatment. In vitro and in vivo experiments proved the potential of the NiCuFe-S nanotheranostic agent for chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy for cervical cancer.This research not only overcomes inherent limitations but also significantly broadens the applications of Prussian blue analogues in biomedicine.© 2024 Xu et al.