发育内皮基因座 1 (DEL-1)，也称为 EGF 样重复序列和盘状蛋白 I 样结构域 3 (EDIL3)，因其在免疫调节和血管生物学中的多方面作用而日益得到认可。 DEL-1是一种主要由内皮细胞产生的蛋白质。它与各种整合素相互作用，调节免疫细胞的行为，例如防止不必要的募集和炎症。 DEL-1 还通过促进胞吞作用（清除凋亡细胞的过程）来帮助解决炎症。由于其对血管完整性和病理学的广泛影响，其作为免疫介导的血液疾病、心血管疾病和癌症转移的治疗靶点的潜力受到关注。然而，关于DEL-1的精确功能和机制仍然存在未解之谜。本综述对 DEL-1 在不同血管环境中的活性进行了全面检查，并探讨了其潜在的临床应用。它强调需要进一步研究来解决现有争议并确定 DEL-1 调制的治疗可行性。版权所有 © 2024 Jiang、Yue、Liang 和 Wu。

Developmental Endothelial Locus-1 (DEL-1), also known as EGF-like repeat and discoidin I-like domain-3 (EDIL3), is increasingly recognized for its multifaceted roles in immunoregulation and vascular biology. DEL-1 is a protein that is mainly produced by endothelial cells. It interacts with various integrins to regulate the behavior of immune cells, such as preventing unnecessary recruitment and inflammation. DEL-1 also helps in resolving inflammation by promoting efferocytosis, which is the process of clearing apoptotic cells. Its potential as a therapeutic target in immune-mediated blood disorders, cardiovascular diseases, and cancer metastasis has been spotlighted due to its wide-ranging implications in vascular integrity and pathology. However, there are still unanswered questions about DEL-1's precise functions and mechanisms. This review provides a comprehensive examination of DEL-1's activity across different vascular contexts and explores its potential clinical applications. It underscores the need for further research to resolve existing controversies and establish the therapeutic viability of DEL-1 modulation.Copyright © 2024 Jiang, Yue, Liang and Wu.