六种有机锡 (IV) 配合物，即 [Me2Sn(L)] (1)、[n-Bu2Sn(L)] (2)、[n-Oct2Sn(L)] (3)、[Bz2Sn(L)] ·0.5C7H8 (4)、[n-BuSn(L)Cl] (5) 和 [PhSn(L)Cl] (6) 使用 2,6-二乙酰基吡啶双(2-羟基苯甲酰腙) H2L 合成。通过傅里叶变换红外 (FT-IR)、高分辨率质谱 (HRMS) 和溶液傅里叶变换核磁共振 (FT-NMR) 光谱对化合物进行了表征。通过单晶X射线衍射(SC-XRD)分析建立了结构1-6。衍射结果证明配合物 1-6 是七配位单核物种，其赤道面包含双去质子化 L 的五边形 N3O2 螯合环和两个轴向配体，R (R = Me、n-Bu、n-Oct、Bz ) 或 R (n-Bu 或 Ph) 和 Cl 配体。此外，由于分子的共轭性和刚性增强，因此检查了光物理性质，同时进行了热重分析以评估化合物的热稳定性。测试了复合物1-6针对前列腺癌细胞(DU-145)和正常人胚胎肾细胞(HEK-293)的抗增殖活性。其中，二丁基锡化合物 2 表现出增强的抗增殖活性，IC50 值为 6.16 ± 1.56 μM。其作用机制的研究涉及使用 AO/EB（吖啶橙/溴化乙锭）和 ROS（活性氧）生成测定。这可能检测到细胞核中的凋亡形态变化，ROS 的产生最终导致细胞凋亡和细胞死亡。 2的优异活性可能归因于C…H接触以及距赫什菲尔德表面各自较高的de外部和di内部距离。因此，这些化合物可能成为经典化疗药物的有前途的替代品。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Six organotin(IV) complexes, viz., [Me2Sn(L)] (1), [n-Bu2Sn(L)] (2), [n-Oct2Sn(L)] (3), [Bz2Sn(L)]·0.5C7H8 (4), [n-BuSn(L)Cl] (5), and [PhSn(L)Cl] (6), were synthesized using a 2,6-diacetylpyridine bis(2-hydroxybenzoylhydrazone), H2L. Compounds were characterized by Fourier transform infrared (FT-IR), High-resolution mass spectrometry (HRMS), and solutions Fourier transform nuclear magnetic resonance (FT-NMR) spectroscopies. The structures 1-6 were established by single-crystal X-ray diffraction (SC-XRD) analysis. Diffraction results evidenced that complexes 1-6 were seven-coordinated mononuclear species with the equatorial plane comprising the pentagonal N3O2 chelate ring of the doubly deprotonated L and two axial ligands, either R (R = Me, n-Bu, n-Oct, Bz) or R (n-Bu or Ph) and Cl ligands. Additionally, the photophysical properties were examined due to the enhanced conjugation and rigidity of the molecules while thermogravimetric analysis was carried out to evaluate the thermal stabilities of compounds. The anti-proliferative activity of the complexes 1-6 was tested against prostate cancer cells (DU-145) and normal human embryonic kidney cells (HEK-293). Among the compounds, dibutyltin compound 2 exhibited increased anti-proliferative activity, with an IC50 value of 6.16 ± 1.56 μM. The investigation of its mechanism of action involves using AO/EB (acridine orange/ethidium bromide) and ROS (reactive oxygen species) generation assays. This likely detects apoptotic morphological alterations in the nucleus of the cells, with ROS generation ultimately leading to apoptosis and cell death. The superior activity of 2 may be attributed to the C···H contacts and respective higher de outside and di inside distances from the Hirshfeld surface. Thus, these compounds could be a promising alternative to classical chemotherapy agents.Copyright © 2024 Elsevier Inc. All rights reserved.