基于 MRI 的口腔鳞状细胞癌下颌舌骨肌评估,一种 7 分评分方法。
MRI-based assessment of the mylohyoid muscle in oral squamous cell carcinoma, a 7-point scoring method.
发表日期:2024 Aug 29
作者:
E Radin, A V Marcuzzo, J de Groodt, F Degrassi, L Calderan, V Ramella, G Tirelli, M Ukmar, M A Cova
来源:
EUROPEAN RADIOLOGY
摘要:
目的 研究术前 MRI 评估下颌舌骨肌 (MM) 的特征,预测其在口腔鳞状细胞癌 (OSCC) 治疗计划中的浸润,确定最合适的序列来研究其深入口底 (FOM) 的情况。我们采用 7 分评分来回顾性评估 11 年以上接受 OSCC 手术的患者的术前影像学。使用斯皮尔曼等级系数将结果与组织病理学结果进行比较。采用受试者工作特征曲线来评估评分预测 MM 浸润的能力,确定敏感性、特异性和预测值的最佳阈值。曼-惠特尼 U 检验证实,渗透判断在该阈值附近没有重叠。 Cohen's K 统计系数用于评估观察者间的一致性。对 52 名患者(平均年龄 66.4±11.9 岁,36 名男性)进行了评估。组织病理学检查发现 21% 的病例 (n = 11) 存在 MM 浸润,其中 90% 属于最高评分类别。评分 > 4被证明是预测MM浸润风险的最佳临界值,敏感性为91%(CI:0.57-0.99),特异性为61%(CI:0.45-0.76),PPV 38%(CI) :0.21-0.59),净现值 96%(CI:0.78-0.99)。在随后的单序列评估中,TSE-T2wi 的诊断准确性最高,敏感性为 90%(CI:0.57-0.99),特异性为 70%(CI:0.53-0.82),PPV 45%(CI:0.25-0.67) ) 和 NPV 96% (CI: 0.80-0.99)。7 分评分是 OSCC 治疗中 MM 安全手术切缘的一个有希望的预测指标,特别有 T2 加权序列的好处。我们的肿瘤浸润评分系统MM 即使对于经验不足的放射科医生来说也很容易使用,可以实现放射学语言的统一,从而确保为外科医生提供重要的术前信息。MM 与口腔病变的关系可能会影响手术计划。随着评分的增加,MM 中浸润的发生率也随之增加。我们的评分系统改善了放射科医生对肿瘤累及 MM 的报告。© 2024。作者。
To investigate preoperative MRI evaluation of the features of the mylohyoid muscle (MM) predictive of its infiltration in oral squamous cell carcinoma (OSCC) treatment planning, defining the most appropriate sequences to study its deep extension into the floor of the mouth (FOM).We applied a 7-point score to retrospectively evaluate preoperative imaging of patients who underwent surgery for OSCC over 11 years. The results were compared with histopathological findings using Spearman's rank coefficient. Receiver operating characteristic curves were employed to assess the score's ability to predict MM infiltration, determining optimal thresholds for sensitivity, specificity, and predictive values. The Mann-Whitney U-test confirmed that infiltration judgments did not overlap around this threshold. Cohen's K statistical coefficient was used to evaluate the interobserver agreement.Fifty-two patients (mean age 66.4 ± 11.9 years, 36 men) were evaluated. Histopathological examination found MM infiltration in 21% of cases (n = 11), with 90% classified in the highest Score categories. A score > 4 proved to be the best cut-off for predicting the risk of MM infiltration, with a sensitivity of 91% (CI: 0.57-0.99), specificity 61% (CI: 0.45-0.76), PPV 38% (CI: 0.21-0.59), and NPV 96% (CI: 0.78-0.99). At the subsequent single-sequence assessment, the TSE-T2wi had the highest diagnostic accuracy, with sensitivity 90% (CI: 0.57-0.99), specificity 70% (CI: 0.53-0.82), PPV 45% (CI: 0.25-0.67), and NPV 96% (CI: 0.80-0.99).The 7-point score is a promising predictor of safe surgical margins for MM in OSCC treatment, with the particular benefit of T2-weighted sequences.Our scoring system for tumor infiltration of MM, which is easy to use even for less experienced radiologists, allows for uniformity in radiological language, thereby ensuring crucial preoperative information for the surgeon.The relationship of the MM to an oral lesion may impact surgical planning. As the score increases, there is a greater incidence of infiltration in the MM. Our score system improves radiologists' reporting for MM involvement by tumor.© 2024. The Author(s).