这篇综合综述探讨了内分泌干扰化学物质 (EDC) 与睾丸生殖细胞肿瘤 (TGCT) 发展之间复杂的相互作用。尽管TGCT的治愈率很高，但诊断和治疗方面的挑战仍然存在，需要更深入地了解该疾病的病因。在此，我们强调目前对 EDC 作为 TGCT 潜在风险因素的认识，重点关注农药以及全氟和多氟烷基物质 (PFA/PFC)。有证据表明，EDC 会破坏内分泌途径并诱导表观遗传变化，从而促进 TGCT 的发展。然而，EDC 和 TGCT 之间的直接联系仍然难以捉摸，需要进一步研究分子机制。我们还强调了研究核受体作为理解 TGCT 病因学潜在靶点的重要性。此外，最近的证据表明 PFA/PFC 与 TGCT 发病率有关，强调需要进一步研究其对人类健康的影响。总的来说，这篇综述为 EDC 在 TGCT 发展中的潜在作用提供了宝贵的见解，并为未来的研究提出了途径，同时还强调了了解它们的影响如何为改善疾病管理的新治疗方法铺平道路。版权所有 © 2024。由 Elsevier 出版有限公司

This comprehensive review examines the complex interplay between endocrine disrupting chemicals (EDCs) and the development of testicular germ cell tumors (TGCTs). Despite the high cure rates of TGCTs, challenges in diagnosis and treatment remain, necessitating a deeper understanding of the etiology of the disease. Here, we emphasize current knowledge on the role of EDCs as potential risk factors for TGCTs, focusing on pesticides and perfluorinated and polyfluoroalkyl substances (PFAs/PFCs). Evidence suggests that EDCs disrupt endocrine pathways and induce epigenetic changes that contribute to the development of TGCTs. However, the direct link between EDCs and TGCTs remains elusive and requires further investigation of the molecular mechanisms. We also highlighted the importance of studying nuclear receptors as potential targets for understanding TGCT etiology. In addition, recent evidence implicates PFAs/PFCs in TGCT incidence, highlighting the need for further research into their impact on human health. Overall, this review provides valuable insights into the potential role of EDCs in TGCT development and suggests avenues for future research, while also highlighting how understanding their influence may pave the way for novel therapeutic approaches to improve disease management.Copyright © 2024. Published by Elsevier Ltd.