PD-1 阻断是局部晚期直肠癌新辅助放化疗的一种有前景的治疗补充。
PD-1 blockade is a promising therapeutic addition to neoadjuvant chemoradiation in locally advanced rectal cancer.
发表日期：2024 Aug 12
作者：
Ashwin Somasundaram, Hanna K Sanoff
来源：
CANCER CELL
摘要：
新辅助放化疗一直是局部晚期直肠癌治疗的支柱。程序性细胞死亡蛋白 1 (PD-1) 阻断疗法与放射疗法联合使用已证明有效。在本期中，Xiao 等人。通过在新辅助治疗中添加 PD-1 阻断剂来治疗错配修复良好的直肠癌，显示出良好的疗效。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Neoadjuvant chemoradiotherapy has been a mainstay of the treatment of locally advanced rectal cancer. Programmed cell death protein 1 (PD-1) blockade therapy has demonstrated efficacy in combination with radiation. In this issue, Xiao et al. demonstrate promising efficacy with the addition of PD-1 blockade to neoadjuvant therapy for mismatch-repair proficient rectal cancer.Copyright © 2024 Elsevier Inc. All rights reserved.