KRAS 突变谱及其在胰腺癌中的临床意义。
The KRAS mutational spectrum and its clinical implications in pancreatic cancer.
发表日期：2024 Aug 20
作者：
Luigi Perelli, Giannicola Genovese, Giulio F Draetta
来源：
CANCER CELL
摘要：
在本期《癌细胞》中，McIntyre 等人。表明 KRAS 原癌基因的特定突变影响胰腺导管腺癌 (PDAC) 的临床进展。重要的是，他们发现 KRASG12R 突变在早期 PDAC 中富集，其特征是明显激活的分子程序。版权所有 © 2024 Elsevier Inc. 保留所有权利。
In this issue of Cancer Cell, McIntyre et al. show that specific mutations in the KRAS proto-oncogene shape clinical progression of pancreatic ductal adenocarcinoma (PDAC). Importantly, they find that the KRASG12R mutation is enriched in early-stage PDAC, and it is characterized by distinctly activated molecular programs.Copyright © 2024 Elsevier Inc. All rights reserved.