背景：结直肠癌是胃肠道常见恶性肿瘤中死亡的主要原因。尽管化疗是结直肠癌的标准治疗方法，但其疗效受到化疗耐药性的限制。最近的研究调查了靶向肿瘤干细胞作为解决结直肠癌化疗耐药性的潜在新治疗方法。结直肠癌经常复发，肿瘤干细胞通常是治疗失败的主要原因之一。目的：了解结直肠癌干细胞的耐药性对于改善治疗结果至关重要。通过专注于开发专门解决结直肠癌干细胞耐药性的靶向疗法，有可能在结直肠癌的治疗方面取得重大进展。这种方法可能会给结直肠癌患者带来更有效和持久的结果。研究设计：在这篇综述中，全面概述了结直肠癌干细胞治疗耐药性的最新研究。结果：阐明了关键的潜在机制。该综述还强调了靶向治疗在克服结直肠癌治疗耐药性方面的潜在益处。结论：CCSC 是 CRC 耐药性的关键参与者，表明它们作为有效治疗靶点的潜力。阐明它们在此过程中的作用可能有助于发现量身定制的治疗策略。信号通路、TME 和 miRNA 在调节 CCSC 耐药性中的重要性得到了强调。

Background: Colorectal cancer is a major cause of mortality among the prevalent malignant tumors of the gastrointestinal tract. Although chemotherapy is a standard treatment for colorectal cancer, its efficacy is limited by chemoresistance. Recent studies have investigated targeting tumor stem cells as a potential new therapeutic approach for addressing chemoresistance in colorectal cancer. Colorectal cancer frequently relapses, with tumor stem cells often representing one of the leading causes of treatment failure. Purpose: Understanding drug resistance in colorectal cancer stem cells is crucial for improving treatment outcomes. By focusing on developing targeted therapies that specifically address drug resistance in colorectal cancer stem cells, there is potential to make significant advancements in the treatment of colorectal cancer.This approach may lead to more effective and lasting outcomes in patients battling colorectal cancer. Research Design: In this review, a comprehensive overview of recent research on colorectal cancer stem cell treatment resistance is presented.Results: Elucidating the key underlying mechanisms. This review also highlights the potential benefits of targeted therapies in overcoming colorectal cancer resistance to treatment. Conclusions: CCSCs are key players in drug resistance of CRC, indicating their potential as targets for effective therapy. Elucidating their role in this process could aid in discovering tailored treatment strategies.The significance of signaling pathways, TME, and miRNA in regulating drug resistance in CCSCs is been highlighted.