活性氧（ROS）是正常细胞代谢产生的一组高活性分子，在人体中发挥着至关重要的作用。近年来，研究人员越来越多地发现ROS在慢性炎症和肿瘤转移的进展中发挥着至关重要的作用。慢性炎症建立的炎症肿瘤微环境可以通过炎症细胞诱导ROS产生。 ROS可以直接损伤DNA或间接激活细胞信号通路，促进肿瘤转移和发展，包括乳腺癌、肺癌、肝癌、结直肠癌等。本综述旨在阐明ROS、慢性炎症和肿瘤转移之间的关系，解释慢性炎症如何诱导肿瘤转移以及ROS如何促进慢性炎症向肿瘤转移的演变。有趣的是，ROS具有“双刃剑”效应，在某些情况下促进肿瘤转移，在另一些情况下抑制肿瘤转移。本文还重点介绍了ROS在抑制肿瘤转移、提高肿瘤靶向治疗精准度方面的潜在应用。将 ROS 与纳米材料策略相结合可能是增强肿瘤治疗功效的一种有前景的方法。版权所有 © 2024。由 Elsevier B.V. 出版。

Reactive oxygen species (ROS) are a group of highly active molecules produced by normal cellular metabolism and play a crucial role in the human body. In recent years, researchers have increasingly discovered that ROS plays a vital role in the progression of chronic inflammation and tumor metastasis. The inflammatory tumor microenvironment established by chronic inflammation can induce ROS production through inflammatory cells. ROS can then directly damage DNA or indirectly activate cellular signaling pathways to promote tumor metastasis and development, including breast cancer, lung cancer, liver cancer, colorectal cancer, and so on. This review aims to elucidate the relationship between ROS, chronic inflammation, and tumor metastasis, explaining how chronic inflammation can induce tumor metastasis and how ROS can contribute to the evolution of chronic inflammation toward tumor metastasis. Interestingly, ROS can have a "double-edged sword" effect, promoting tumor metastasis in some cases and inhibiting it in others. This article also highlights the potential applications of ROS in inhibiting tumor metastasis and enhancing the precision of tumor-targeted therapy. Combining ROS with nanomaterials strategies may be a promising approach to enhance the efficacy of tumor treatment.Copyright © 2024. Published by Elsevier B.V.