青少年常见的恶性骨肿瘤是骨肉瘤。化疗、手术治疗和放射治疗共同构成骨肉瘤的常规临床治疗过程。虽然骨肉瘤和其他骨肿瘤通常通过手术治疗，但手术切除往往无法彻底根除肿瘤，进而成为术后复发和转移的主要原因，最终导致较高的死亡率。患者在手术后仍然需要放疗和/或化疗来阻止肿瘤的扩散及其转移，这两种治疗都会对身体的器官系统产生不利影响。在骨肉瘤的术后治疗中，骨支架可以装载货物（生长因子或药物）并充当药物输送系统（DDS）。这篇综述描述了目前可用的不同类型的骨支架，并重点介绍了使用支架作为 DDS 治疗骨肉瘤的关键研究。讨论还包括有关使用基于支架的 DDS 的困难和观点。该研究可作为概述有效且安全的术后骨肉瘤治疗计划的来源。

A common malignant bone neoplasm in teenagers is Osteosarcoma. Chemotherapy, surgical therapy, and radiation therapy together comprise the usual clinical course of treatment for Osteosarcoma. While Osteosarcoma and other bone tumors are typically treated surgically, however, surgical resection frequently fails to completely eradicate tumors, and in turn becomes the primary reason for postoperative recurrence and metastasis, ultimately leading to a high rate of mortality. Patients still require radiation and/or chemotherapy after surgery to stop the spread of the tumor and its metastases, and both treatments have an adverse influence on the body's organ systems. In the postoperative management of osteosarcoma, bone scaffolds can load cargos (growth factors or drugs) and function as drug delivery systems (DDSs). This review describes the different kinds of bone scaffolds that are currently available and highlights key studies that use scaffolds as DDSs for the treatment of osteosarcomas. The discussion also includes difficulties and perspectives regarding the use of scaffold-based DDSs. The study may serve as a source for outlining efficient and secure postoperative osteosarcoma treatment plans.