癌症干细胞 (CSC) 是一种低分化的恶性细胞群，（至少在某些肿瘤中）是导致肿瘤进展、治疗耐药和疾病复发的原因。根据广泛接受的模型，癌症进展的所有阶段都涉及肿瘤细胞逃避宿主免疫系统识别或消除的能力。根据这一概念，CSC 不仅能够比分化程度更高的同类更好地应对环境和治疗引起的压力，而且似乎能够更好地逃避肿瘤靶向免疫反应。我们总结了 CSC 逃避免疫识别或消除的 DNA 和组蛋白的表观遗传修饰，并提出此类改变构成有希望的治疗靶点，以提高某些恶性肿瘤对免疫治疗的敏感性。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Cancer stem cells (CSCs) are a poorly differentiated population of malignant cells that (at least in some neoplasms) is responsible for tumor progression, resistance to therapy, and disease relapse. According to a widely accepted model, all stages of cancer progression involve the ability of neoplastic cells to evade recognition or elimination by the host immune system. In line with this notion, CSCs are not only able to cope with environmental and therapy-elicited stress better than their more differentiated counterparts but also appear to better evade tumor-targeting immune responses. We summarize epigenetic modifications of DNA and histones through which CSCs evade immune recognition or elimination, and propose that such alterations constitute promising therapeutic targets to increase the sensitivity of some malignancies to immunotherapy.Copyright © 2024 Elsevier Inc. All rights reserved.