胶质瘤是成人中枢神经系统最常见的原发性神经上皮肿瘤，其中胶质母细胞瘤是最致命的亚型。除了胶质瘤（干）细胞本质上坚不可摧的特性外，越来越多的证据表明，肿瘤微环境在胶质母细胞瘤的难治性中也起着至关重要的作用。血小板的主要功能是在生理条件下止血和调节血栓形成。此外，血小板也是参与肿瘤发展多种过程的活性元件，包括肿瘤生长、侵袭和化疗耐药。神经胶质瘤细胞招募并激活静息血小板，使其成为肿瘤教育血小板（TEP），进而促进神经胶质瘤细胞的增殖、侵袭、干细胞性和化疗耐药性。 TEP可用于获取胶质瘤的遗传信息，有助于早期诊断和监测治疗效果。血小板膜是一种有趣的仿生材料，可用于开发有效的药物载体以增强抗神经胶质瘤活性。本文回顾了近年来有关血小板对胶质瘤恶性特征的贡献的研究，重点关注介导TEP与胶质瘤（干）细胞相互作用的分子机制，并提出了靶向血小板治疗胶质瘤的挑战和机遇。版权所有 © 2024 中华医学会，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 许可制作。

Gliomas are the most common primary neuroepithelial tumors of the central nervous system in adults, of which glioblastoma is the deadliest subtype. Apart from the intrinsically indestructible characteristics of glioma (stem) cells, accumulating evidence suggests that the tumor microenvironment also plays a vital role in the refractoriness of glioblastoma. The primary functions of platelets are to stop bleeding and regulate thrombosis under physiological conditions. Furthermore, platelets are also active elements that participate in a variety of processes of tumor development, including tumor growth, invasion, and chemoresistance. Glioma cells recruit and activate resting platelets to become tumor-educated platelets (TEPs), which in turn can promote the proliferation, invasion, stemness, and chemoresistance of glioma cells. TEPs can be used to obtain genetic information about gliomas, which is helpful for early diagnosis and monitoring of therapeutic effects. Platelet membranes are intriguing biomimetic materials for developing efficacious drug carriers to enhance antiglioma activity. Herein, we review the recent research referring to the contribution of platelets to the malignant characteristics of gliomas and focusing on the molecular mechanisms mediating the interaction between TEPs and glioma (stem) cells, as well as present the challenges and opportunities in targeting platelets for glioma therapy.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.