本研究的目的是探讨影响多形性胶质母细胞瘤（GBM）患者切除后接受光动力治疗（PDT）的脑水肿和颅内压的因素。范围为2021年5月至2023年8月，收集GBM患者的基线临床资料、脑水肿量、颅内压值及影像学数据进行统计分析。共纳入56例GBM患者。其中 30 名患者接受了大体全切除术 (GTR)，另外 26 名患者接受了次全切除术 (STR)。我们发现接受GTR的患者的脑水肿体积和平均颅内压低于接受STR的患者。而且单因素分析显示，肿瘤切除范围是影响PDT术后脑水肿和颅内压的独立因素。与STR相比，PDT联合GTR显着降低GBM患者术后脑水肿体积和颅内压。© 2024 Wiley periodicals LLC 。

The aim of our study was to explore the factors influencing cerebral edema and intracranial pressure in glioblastoma multiforme (GBM) patients who undergo photodynamic therapy (PDT) after resection.This was a retrospective controlled study of GBM patients treated with PDT-assisted resections of varying scope from May 2021 to August 2023. The baseline clinical data, cerebral edema volumes, intracranial pressure values, and imaging data of the GBM patients were collected for statistical analysis.A total of 56 GBM patients were included. Thirty of the patients underwent gross total resection (GTR), and the other 26 patients underwent subtotal resection (STR). We found that the cerebral edema volume and the mean intracranial pressure in patients who underwent GTR were lower than those in patients who underwent STR. Moreover, univariate analysis showed that the scope of tumor resection was an independent factor affecting cerebral edema and intracranial pressure after PDT.Compared with STR, PDT combined with GTR significantly reduced postoperative brain edema volume and intracranial pressure in GBM patients.© 2024 Wiley Periodicals LLC.