趋化因子受体对于口腔和肠道粘膜的免疫反应至关重要。胃肠粘膜的特点是存在免疫群体，因为它容易受到炎症和传染病的影响，因此需要免疫监视。趋化因子受体在免疫细胞上表达，并在胃肠道组织归巢中发挥作用，尽管其他非免疫细胞也表达它们以实现各种生物学功能。 CCR9、CXCR3 和 CXCR6 在胃肠道粘膜炎症和肿瘤性疾病的 T 细胞反应中发挥重要作用。然而，CXCR6 也可以在胃癌细胞中发现，这凸显了趋化因子受体在不同病理中的不同作用。另一方面，CCR4 和 CCR8 对于胃肠道组织中的 Treg 迁移至关重要，与粘膜癌的不良预后相关。其他趋化因子受体在促进骨髓浸润方面也很重要，其作用具有背景依赖性。此外，CXCR4 和 CXCR7 也存在于胃肠道肿瘤细胞中，并且已知可刺激增殖、迁移和侵入其他组织，以及其他促肿瘤发生功能。确定粘膜免疫的基本过程并为胃肠道疾病创建量身定制的治疗方法需要了解这些粘膜组织中趋化因子受体及其配体之间发生的复杂相互作用。版权所有 © 2024。由爱思唯尔公司出版。

Chemokine receptors are essential for the immune response in the oral and gut mucosa. The gastrointestinal mucosa is characterized by the presence of immune populations because it is susceptible to inflammatory and infectious diseases, necessitating immune surveillance. Chemokine receptors are expressed on immune cells and play a role in gastrointestinal tissue-homing, although other non-immune cells also express them for various biological functions. CCR9, CXCR3 and CXCR6 play an important role in the T cell response in inflammatory and neoplastic conditions of the gastrointestinal mucosa. However, CXCR6 could also be found in gastric cancer cells, highlighting the different roles of chemokine receptors in different pathologies. On the other hand, CCR4 and CCR8 are critical for Treg migration in gastrointestinal tissues, correlating with poor prognosis in mucosal cancers. Other chemokine receptors are also important in promoting myeloid infiltration with context-dependent roles. Further, CXCR4 and CXCR7 are also present in gastrointestinal tumor cells and are known to stimulate proliferation, migration, and invasion into other tissues, among other pro-tumorigenic functions. Determining the processes underlying mucosal immunity and creating tailored therapeutic approaches for gastrointestinal diseases requires an understanding of the complex interactions that occur between chemokine receptors and their ligands in these mucosal tissues.Copyright © 2024. Published by Elsevier Inc.