甲状腺癌（TC）是内分泌系统最常见的恶性肿瘤。本研究旨在评估 2022 年 TC 发病率和死亡率的全球分布，并预测 2050 年的负担。使用 GLOBOCAN 2022 数据库的数据分析按性别划分的 TC 年龄标准化发病率和死亡率、年龄组（<55 岁和≥55 岁）、国家、世界地区以及 185 个国家的人类发展指数 (HDI) 水平。根据人口预测计算了 2050 年的预测发病率和死亡率负担。 2022 年，全球估计发生 821,214 例新发 TC 病例和 47,507 例 TC 相关死亡。女性的年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）（ASIR：13.60/100,000；ASMR：0.53/100,000）高于男性（ASIR：4.60/100,000；ASMR：0.35/100,000） ）。对于男女而言，高 HDI 国家的 ASIR 大约比低 HDI 国家高出十倍，而且各地区的 ASMR 相对相似。在185个国家中，中国的TC病例数（占总病例数的56.77%）和TC相关死亡数（占全球TC相关死亡数的24.35%）最多，男性ASIR最高（每10万人13.30） 。在全球范围内，约64.63%的TC病例发生在55岁以下人群，而近82.99%的TC相关死亡发生在55岁及以上人群。如果与 2022 年保持相同，预计 2050 年将出现约 1,100,000 例新发 TC 病例和 91,000 例 TC 相关死亡，分别增加 34.15% 和 89.58%。 TC 是世界范围内的一种高发癌症，但存在差异跨地区、跨性别、跨年龄组。我们的结果揭示了全球 TC 疾病负担，并促进了区域定制的预防措施。版权所有 © 2024 The Chinese Medical Association，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 许可制作。

Thyroid cancer (TC) is the most common malignancy of the endocrine system. This study aimed to assess the global distribution of TC incidence and mortality in 2022, as well as to predict the burden for the year 2050.Data from the GLOBOCAN 2022 database were used to analyze the age-standardized incidence and mortality rates of TC by sex, age group (<55 years and ≥55 years), country, world region, and level of Human Development Index (HDI) for 185 countries. The predicted incidence and mortality burden for 2050 was calculated based on demographic projections.In 2022, an estimated 821,214 new TC cases and 47,507 TC-related deaths occurred worldwide. The age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were higher in women (ASIR: 13.60 per 100,000; ASMR: 0.53 per 100,000) than in men (ASIR: 4.60 per 100,000; ASMR: 0.35 per 100,000). The ASIR in high HDI countries was approximately ten times higher than that in low HDI countries for both sexes, with relatively similar ASMR across regions. Among 185 countries, China had the largest number of TC cases (accounting for 56.77% of total cases) and TC-related deaths (accounting for 24.35% of global TC-related deaths), with the highest ASIR in men (13.30 per 100,000). Worldwide, approximately 64.63% of TC cases occurred in populations under 55 years old, while nearly 82.99% of TC-related deaths occurred in populations aged 55 years and above. If the rates stay the same as in 2022, it is projected that approximately 1,100,000 new TC cases and 91,000 TC-related deaths will occur in 2050, indicating a 34.15% and 89.58% increase, respectively.TC is a highly frequent cancer worldwide with disparities across regions, genders, and age groups. Our results provide light on the worldwide TC disease burden and facilitate regionally customized prevention measures.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.