新的证据表明，新陈代谢不仅是细胞分裂的能量和生物材料的来源，而且还是癌细胞可塑性和治疗耐药性的驱动因素。这是因为代谢变化导致染色质重塑和基因表达模式重新编程，从而进一步促进肿瘤细胞表型转变。因此，代谢和表观遗传学之间的相互作用似乎对于发现各种侵袭性肿瘤的新治疗靶点具有巨大的潜力。在这里，我们重点介绍最近的发现，这些发现支持新陈代谢和表观遗传学之间的合作使癌症能够克服治疗引起的不断增加的压力的概念。我们讨论了特定代谢物如何促进癌细胞的恢复力，并提供了关于同时靶向这些关键力量如何产生协同治疗效果以改善治疗结果的观点。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Emerging evidence indicates that metabolism not only is a source of energy and biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment resistance. This is because metabolic changes lead to remodeling of chromatin and reprogramming of gene expression patterns, furthering tumor cell phenotypic transitions. Therefore, the crosstalk between metabolism and epigenetics seems to hold immense potential for the discovery of novel therapeutic targets for various aggressive tumors. Here, we highlight recent discoveries supporting the concept that the cooperation between metabolism and epigenetics enables cancer to overcome mounting treatment-induced pressures. We discuss how specific metabolites contribute to cancer cell resilience and provide perspective on how simultaneously targeting these key forces could produce synergistic therapeutic effects to improve treatment outcomes.Copyright © 2024 Elsevier Inc. All rights reserved.