深入了解与多形性腺瘤恶性表型获得相关的 PLAG1 和 HMGA2 分子改变。
Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma.
发表日期：2024 Sep 13
作者：
Reydson Alcides de Lima-Souza, Gustavo de Souza Vieira, Talita de Carvalho Kimura, João Figueira Scarini, Luccas Lavareze, Tayná Figueiredo Maciel, Moisés Willian Aparecido Gonçalves, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
摘要：
多形性腺瘤（PA）是唾液腺最常见的肿瘤，具有多种组织学特征。在某些情况下，PA 可能会恶变为多形性腺瘤癌 (CXPA)。从 PA 到 CXPA 的转变与复杂的分子改变有关，特别是涉及多形性腺瘤基因 1 (PLAG1) 和高迁移率族蛋白基因 (HMGA2)。本综述探讨了 PA 恶性转化过程中 PLAG1 和 HMGA2 在所有域中的分子改变。我们的分析强调，这些标记是 PA 和 CXPA 发病机制的关键改变，基因融合和扩增是经常报道的机制。尽管PLAG1和HMGA2在致癌过程中的确切作用仍不清楚，但需要对HMGA2和PLAG1进行进一步研究，特别是HMGA2-PLAG1-IGF2，这被证明是开发临床适用疗法的潜在途径，特别是对于CXPA 管理。版权所有 © 2024 Elsevier B.V. 保留所有权利。
Pleomorphic adenoma (PA) is the most common neoplasm of the salivary gland, presenting with a variety of histological features. In some cases, PA can undergo malignant transformation to carcinoma ex pleomorphic adenoma (CXPA). The transition from PA to CXPA is associated with complex molecular alterations, particularly involving the pleomorphic adenoma gene 1 (PLAG1) and high mobility group protein gene (HMGA2). This review investigates the molecular alterations of PLAG1 and HMGA2 in all domains in the malignant transformation of PA. Our analysis highlights that these markers are key alterations in the etiopathogenesis of PA and CXPA, with gene fusion and amplification being frequently reported mechanisms. Although the exact role of PLAG1 and HMGA2 in the oncogenic process remains unclear, further studies on the HMGA2 and PLAG1, are needed particularly in HMGA2-PLAG1-IGF2 which is proving to be a potential pathway for the development of clinically applicable therapies, especially for CXPA management.Copyright © 2024 Elsevier B.V. All rights reserved.