甲基转移酶样蛋白是人体内普遍存在的类酶蛋白，具有核酸、蛋白质和其他小分子的结合域，在正常生物体和疾病的多种生物学行为中发挥着重要作用，其特征是存在甲基转移酶样结构域和由蛋白质中心的七链β折叠结构形成的结构保守的SAM结合域。随着研究的深入，METTL蛋白家族被发现在多种肿瘤疾病中异常表达，阐明其与肿瘤疾病的关系可作为分子治疗靶点，对肿瘤的预后具有重要作用。肿瘤。本文对METTL蛋白家族的结构、生物学过程、免疫治疗、靶向药物治疗和标志物等进行综述，为肿瘤的诊断和治疗提供新思路。© 2024。作者。

Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a methyltransferase-like structural domain and a structurally conserved SAM-binding domain formed by the seven-stranded β-fold structure in the center of the protein. With the deepening of research, the METTL protein family has been found to be abnormally expressed in a variety of tumor diseases, and the clarification of its relationship with tumor diseases can be used as a molecular therapeutic target and has an important role in the prognosis of tumors. In this paper, we review the structure, biological process, immunotherapy, drug-targeted therapy, and markers of the METTL protein family to provide new ideas for the diagnosis and treatment of tumors.© 2024. The Author(s).