造血干细胞（HSC）和白血病干细胞（LSC）分别对于确保造血稳态和驱动白血病进展至关重要。最近的研究表明，代谢适应显着调节这些干细胞的功能和存活。在这篇综述中，我们概述了代谢途径如何在稳态和衰老过程中调节 HSC 的氧化和蛋白稳态应激。此外，我们强调了可靶向的代谢途径，并探索它们与表观遗传学和微环境的相互作用，以解决 LSC 的化疗耐药性和免疫逃避能力。 HSC 和 LSC 之间的代谢差异对治疗策略具有深远的影响。版权所有 © 2024 Elsevier Ltd。保留所有权利。

Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) are crucial for ensuring hematopoietic homeostasis and driving leukemia progression, respectively. Recent research has revealed that metabolic adaptations significantly regulate the function and survival of these stem cells. In this review, we provide an overview of how metabolic pathways regulate oxidative and proteostatic stresses in HSCs during homeostasis and aging. Furthermore, we highlight targetable metabolic pathways and explore their interactions with epigenetics and the microenvironment in addressing the chemoresistance and immune evasion capacities of LSCs. The metabolic differences between HSCs and LSCs have profound implications for therapeutic strategies.Copyright © 2024 Elsevier Ltd. All rights reserved.