肺癌是最常见的癌症，也是全球癌症相关死亡的主要原因。本研究的目的是评估 2022 年全球肺癌的发病率和死亡率，并预测 2050 年中国和美国肺癌新发病例数和死亡人数。在本研究中，数据来自 GLOBCAN 2022数据库用于分析肺癌的发病率和死亡率。按国家/地区、性别、年龄和人类发展指数 (HDI) 描述了肺癌发病率和死亡的现状，并预测了 2050 年中国和美国未来的肺癌发病率和死亡。据估计，2022年新发肺癌病例为2,480,675例，肺癌相关死亡为1,817,469例，年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）分别为23.6/10万和16.8/10万。在中国，男性肺癌患者的ASIR和ASMR分别约为女性肺癌患者的1.7倍和2.7倍。高HDI国家的ASIR和ASMR分别约为低HDI国家的8.5倍和6.5倍。预计2050年，中国男性新增病例约112万例、死亡96万例，中国女性新增病例68万例、死亡45万例，美国男性新增病例约17万例、死亡11万例，美国男性新增病例约17万例、死亡11万例，美国男性新增病例约17万例、死亡16万例。美国女性新增病例1000余例，死亡9万例。不同地区、不同性别肺癌的发病率和死亡率存在显着差异。因此，在肺癌的预防、筛查和治疗策略中需要考虑性别因素，并积极推动肺癌三级预防措施尤其是一级和二级预防的实施。版权所有©2024中华医学会Association，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 许可制作。

Lung cancer is the most common cancer and a leading cause of cancer-related deaths globally. The aim of this study was to evaluate the incidence and mortality of lung cancer worldwide in 2022 and to project the number of new cases and deaths due to lung cancer in China and the United States in 2050.In this study, data from the GLOBCAN 2022 database were used to analyze lung cancer incidence and mortality. The current status of lung cancer incidence and deaths was described by country/region, sex, age, and the human development index (HDI), and future lung cancer incidence and deaths in China and the United States were projected for 2050.Globally, an estimated 2,480,675 new lung cancer cases and 1,817,469 lung cancer-related deaths occurred in 2022, with age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) of 23.6/100,000 and 16.8/100,000, respectively. In China, the ASIR and ASMR for male lung cancer patients were approximately 1.7 times and 2.7 times greater than those for female lung cancer patients, respectively. The ASIR and ASMR in high-HDI countries were approximately 8.5 times and 6.5 times those in low-HDI countries, respectively. It is estimated that in 2050, there will be approximately 1120 thousand new cases and 960 thousand deaths among Chinese men, 680 thousand new cases and 450 thousand deaths among Chinese women, approximately 170 thousand new cases and 110 thousand deaths among American men, and 160 thousand new cases and 90 thousand deaths among American women.There are significant differences in the incidence and mortality of lung cancer among different regions and sexes. Therefore, sex factors need to be considered in the prevention, screening, and treatment strategies of lung cancer, and the implementation of tertiary prevention measures for lung cancer, especially primary and secondary prevention, needs to be actively promoted.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.