我们之前的研究表明，编码 Aphrocallistes badus 凝集素 (oncoVV-AVL) 的溶瘤痘苗病毒（oncoVV-AVL）是一种经过改造后携带 AVL 的溶瘤痘苗病毒，对结直肠癌细胞和肝细胞癌细胞表现出有效的细胞毒作用。在此基础上，我们进行了一系列实验来探索其对胃癌（GC）细胞的功效。我们的研究结果表明，oncoVV-AVL 显着增加活性氧水平并抑制核因子红细胞 2 相关因子 2 的表达，从而增强病毒复制并破坏细胞氧化还原平衡，最终导致癌细胞死亡。此外，我们的研究发现 oncoVV-AVL 重新编程了代谢微环境以有利于病毒复制，最终导致癌细胞裂解。此外，我们观察到oncoVV-AVL不仅可以抑制肿瘤生长，还可以诱导肿瘤组织坏死。这些有希望的结果表明GC治疗管理的潜在新途径。

Our previous research has demonstrated that the oncolytic vaccinia virus encoding Aphrocallistes vastus lectin (oncoVV-AVL), an oncolytic vaccinia virus engineered to carry the AVL, exhibits potent cytotoxic effects on colorectal and hepatocellular cancer cells. Based on this foundation, we undertook a series of experiments to explore its efficacy on gastric cancer (GC) cells. Our findings revealed that oncoVV-AVL significantly increased reactive oxygen species levels and suppressed the expression of nuclear factor erythroid 2-related factor 2, thereby enhancing viral replication and disrupting the cellular redox balance, ultimately leading to the demise of cancer cells. Additionally, our investigations uncovered that oncoVV-AVL reprogrammed the metabolic microenvironment to favor viral replication, culminating in the lysis of cancer cells. Furthermore, we observed that oncoVV-AVL not only regressed tumor growth but also induced tumor tissue necrosis. These promising results suggest potential new avenues for the therapeutic management of GC.